Journal of the Society for Gynecologic Investigation

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Register here to gain access to SAGE's 500+ Journals Online

SAGETRACK

Sign In to gain access to subscriptions and/or personal tools.
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Amant, F.
Right arrow Articles by Schoenmakers, E. F. P. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Amant, F.
Right arrow Articles by Huys, E.
Right arrow Articles by Geurts-Moespot, A.
Right arrow Articles by Lindeque, B. G.
Right arrow Articles by Vergote, I.
Right arrow Articles by Sweep, F.
Right arrow Articles by Schoenmakers, E. F. P. M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Journal of the Society for Gynecologic Investigation, Vol. 10, No. 2, 105-109 (2003)
DOI: 10.1016/S1071-55760200253-8

Ethnic Variations in Uterine Leiomyoma Biology Are Not Caused By Differences in Myometrial Estrogen Receptor Alpha Levels

Frédéric Amant, MD

Division of Gynecological Oncology, Department of Obstetrics and Gynecology,University Hospitals Leuven, Leuven, Belgium; Department of Human Genetics, University Medical Centre Nijmegen, Nijmegen, The Netherlands; Department of Chemical Endocrinology, University Medical Centre Nijmegen, Nijmegen, The Netherlands; Department of Obstetrics and Gynecology, Pretoria Academic Hospital, Pretoria, South Africa; frederic.amant{at}uz.kuleuven.ac.be

Erik Huys, MSc

Anneke Geurts-Moespot

B. G. Lindeque, MD, PhD

Ignace Vergote, MD, PhD

Fred Sweep, PhD

Eric F. P. M. Schoenmakers, PhD

Division of Gynecological Oncology, Department of Obstetrics and Gynecology,University Hospitals Leuven, Leuven, Belgium; Department of Human Genetics, University Medical Centre Nijmegen, Nijmegen, The Netherlands; Department of Chemical Endocrinology, University Medical Centre Nijmegen, Nijmegen, The Netherlands; Department of Obstetrics and Gynecology, Pretoria Academic Hospital, Pretoria, South Africa

Objective: Uterine leiomyomas develop in women of reproductive age and regress after menopause, suggesting that they grow in a steroid hormone-dependent fashion. Furthermore, it is widely accepted that symptomatic uterine leiomyomas occur at a twofold to threefold higher frequency in black women than in white women. The present study was designed to investigate a possible physiologic role of racial differences in the myometrial estrogen receptor alpha in this phenomenon.

Methods: We compared the expression of the estrogen receptor and progesterone receptor in myometrium by ligand-binding assay and the estrogen receptor alpha by real-time polymerase chain reaction in women from different ethnic backgrounds who have uterine leimyoma.

Results: Estrogen receptor and progesterone receptor concentrations and estrogen receptor alpha transcription levels were not statistically different between ethnic backgrounds.

Conclusion: Neither on a transcriptional nor on a protein level were there statistically relevant differences in steroid hormone receptor levels. A causative role for these receptors in the ethnic variation of leiomyoma biology seems unlikely.

Key Words: Myometrium • leiomyoma • ethnic • ER{alpha} • PR


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?