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Journal of the Society for Gynecologic Investigation
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*Uterine Cancer
*Uterine Fibroids
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Ethnic Variations in Uterine Leiomyoma Biology Are Not Caused By Differences in Myometrial Estrogen Receptor Alpha Levels

Frédéric Amant, MD

Division of Gynecological Oncology, Department of Obstetrics and Gynecology,University Hospitals Leuven, Leuven, Belgium; Department of Human Genetics, University Medical Centre Nijmegen, Nijmegen, The Netherlands; Department of Chemical Endocrinology, University Medical Centre Nijmegen, Nijmegen, The Netherlands; Department of Obstetrics and Gynecology, Pretoria Academic Hospital, Pretoria, South Africa; frederic.amant{at}uz.kuleuven.ac.be

Erik Huys, MSc

Anneke Geurts-Moespot

B. G. Lindeque, MD, PhD

Ignace Vergote, MD, PhD

Fred Sweep, PhD

Eric F. P. M. Schoenmakers, PhD

Division of Gynecological Oncology, Department of Obstetrics and Gynecology,University Hospitals Leuven, Leuven, Belgium; Department of Human Genetics, University Medical Centre Nijmegen, Nijmegen, The Netherlands; Department of Chemical Endocrinology, University Medical Centre Nijmegen, Nijmegen, The Netherlands; Department of Obstetrics and Gynecology, Pretoria Academic Hospital, Pretoria, South Africa

Objective: Uterine leiomyomas develop in women of reproductive age and regress after menopause, suggesting that they grow in a steroid hormone-dependent fashion. Furthermore, it is widely accepted that symptomatic uterine leiomyomas occur at a twofold to threefold higher frequency in black women than in white women. The present study was designed to investigate a possible physiologic role of racial differences in the myometrial estrogen receptor alpha in this phenomenon.

Methods: We compared the expression of the estrogen receptor and progesterone receptor in myometrium by ligand-binding assay and the estrogen receptor alpha by real-time polymerase chain reaction in women from different ethnic backgrounds who have uterine leimyoma.

Results: Estrogen receptor and progesterone receptor concentrations and estrogen receptor alpha transcription levels were not statistically different between ethnic backgrounds.

Conclusion: Neither on a transcriptional nor on a protein level were there statistically relevant differences in steroid hormone receptor levels. A causative role for these receptors in the ethnic variation of leiomyoma biology seems unlikely.

Key Words: Myometrium • leiomyoma • ethnic • ER{alpha} • PR

Journal of the Society for Gynecologic Investigation, Vol. 10, No. 2, 105-109 (2003)
DOI: 10.1016/S1071-55760200253-8
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