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Journal of the Society for Gynecologic Investigation
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Endothelial Nitric Oxide Synthase Polymorphism in Preeclampsia

Tanja Häkli, Cm

Eeva-Liisa Romppanen, PhD

Mikko Hiltunen, PhD

Seppo Helisalmi, PhD

Kari Punnonen, Md, PhD

Departments of Obstetrics and Gynecology, Clinical Chemistry, and Neuroscience and Neurology, Kuopio University and University Hospital, Kuopio, Finland

Seppo Heinonen, Md, PhD

Departments of Obstetrics and Gynecology, Clinical Chemistry, and Neuroscience and Neurology, Kuopio University and University Hospital, Kuopio, Finland; Department of Obstetrics and Gynecology, Kuopio University Hospital, 70211 Kuopio, Finland; seppo.heinonen{at}kuh.fi

objective: We wished to determine whether genetic variability in the gene encoding endothelial nitric oxide synthase (eNOS) modifies individual susceptibility to the development of preeclampsia.

Methods: The study involved 132 preeclamptic and 113 healthy control pregnant women who were genotyped for the Glu298Asp polymorphism in the eNOS gene. X2 analysis was used to assess genotype and allele frequency differences between preeclamptic women and controls.

Results: A statistically similar allelic distribution of eNOS Glu298Asp polymorphism was observed in the two groups, with the frequency of the variant G allele being 74.6% in the preeclampsia group and 67.7% in the control group (P = .91; odds rato 1.40, 95% confidence interval 0.95, 2.01). Accordingly, the genotype distribution of the NOS polymorphism in the preeclamptic and control groups was found to be similar (P = .233).

Conclusion: These genotype data in subjects from eastem Finland were not suggestive of an important contribution of the Glu298Asp polymorphism in the NOS gene on preeclampsia across populations. However, the observed association between the Gallele and disease risk, of borderline significance, may imply that other polymorphism(s) in the gene may modify disease risk.

Key Words: Preeclampsia • polymorphism • NOS

Journal of the Society for Gynecologic Investigation, Vol. 10, No. 3, 154-157 (2003)
DOI: 10.1016/S1071-55760300003-0
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