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Journal of the Society for Gynecologic Investigation
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Polymorphism of the Interleukin-1ß Gene and Endometriosis

Fritz Wieser, MD

Lukas Hefler, MD

Clemens Tempfer, MD

Ulli Vlach, MD

Christian Schneeberger, PhD

Johannes Huber, MD, PhD

Division of Gynecological Endocrinology and Reproductive Medicine, Department of Obstetrics and Gynecology, and Division of Gynecology and Obstetrics, Department of Obstetrics and Gynecology, University of Vienna, Vienna, Austria

Rene Wenzl, MD

Division of Gynecological Endocrinology and Reproductive Medicine, Department of Obstetrics and Gynecology, and Division of Gynecology and Obstetrics, Department of Obstetrics and Gynecology, University of Vienna, Vienna, Austria; Department of Obstetrics and Gynecology, Division of Gynecological Endocrinology & Reproductive Medicine, University of Vienna Medical School, Waehringer Guertel 18-20, A-1090 Vienna, Austria; rene.wenzl{at}akh-wien.ac.at

Objective: Experimental data indicate that interleukin (IL)-1 plays a role in the pathogenesis of endometriosis. We determined the genotype and the allele frequencies of the IL1B exon 5 polymorphism and the corresponding IL-1ß serum levels in women with endometriosis.

Methods: We genotyped 92 women with surgically and histologically confirmed endometriosis and 69 controls without history of endometriosis. Both groups were of middle Euroepan genetic background for the IL1B exon 5 polymorphism (at position +3954). Genotyping was performed by pyrosequencing. IL-1ß serum levels were anlayzed by a commercially available enzyme-linked immunosorbent assay.

Results: Allele frequencies in women with endometriosis and control swere 76.6% and 76.8%, respectively, for the E1 allele (wild type) and 23.4% and 23.2%, respectively, for the E2 allele (polymorphic) (odds ratio 1.01; P > .99). The investigated polymorphism of the IL-1ß gene was not correlated with IL-1ß serum levels.

Conclusion: We did not find an association between the IL1B exon 5 polymorphism, endometriosis, or increased serum IL-1{eta} levels.

Key Words: Endometriosis • polymorphism • interleukin-1

Journal of the Society for Gynecologic Investigation, Vol. 10, No. 3, 172-175 (2003)
DOI: 10.1016/S1071-55760300006-6
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