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Calcium Signaling and Uterine Contractility

Department of Physiology, The University of Liverpool, Liverpool, L69 3BX, UK; s.wray{at}liverpool.ac.uk

K. Jones, PhD

S. Kupittayanant, PhD

Y. Li, MD

A. Matthew, BSc

E. Monir-Bishty, MD

K. Noble, BVSc

S. J. Pierce, MD

S. Quenby, MD

A. V. Shmygol, DSc

Department of Physiology. The University of Liverpool, Liverpool, United Kingdom

Changes in Ca²⁺ signals within the myometrium have important functional consequences, as they determine contractility. We show that the basic phasic nature of uterine contractions, which is essential for successful labor, is critically dependent on Ca²⁺ influx through voltage-gated L-type Ca²⁺ channels, and hence in turn, on membrane potential. Thus changes in ion channel expression around term will play an important role in governing uterine excitability and contractility. There remains uncertainty about which channels are present in human myometrium and the nature of the pacemaker mechanism that initiates the action potential. The sarcoplasmic reticulum may augment, to a small extent, the necessary increase in [Ca²⁺] for contraction when agonists stimulate the uterus, but its main role appears to be to control excitability, acting as a negative feedback mechanism to limit contractions. Myosin light chain kinase activity and phosphorylation of myosin are essential components in the pathway of uterine contraction, once Ca²⁺ has been elevated. Modulation of myosin light chain phosphatase activity can also influence contractions, but the effects are small compared with those modulating myosin light chain kinase, Ca²⁺-sensitizing pathways may not be utilized much in modulating normal phasic uterine activity, and caution is needed in extrapolating from in vitro experiments to in vivo conditions, especially because there may be reduncant pathways. There is a need to study appropriate physiologic preparations, but these are not always available (eg, preterm laborin myometrium) and to combine functional studies with modern moleclar approaches, to advance our understanding to a new level, from which better therapeutic will be developed.

Key Words: Myometrium • contractions • agonists • sarcoplasmic reticulum • ionchannels

Journal of the Society for Gynecologic Investigation, Vol. 10, No. 5, 252-264 (2003)
DOI: 10.1016/S1071-55760300089-3


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