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MMP-1 and MMP-2 Expression in Uterine Leiomyosarcoma and Correlation With Different Clinicopathologic Parameters

Departments of Gynecology and Obstetrics, Anesthesiology, and Gynecopathology, University of Vienna Medical School, Vienna, Austria klausbodner{at}yahoo.com

K. Bodner, MD

O. Kimberger, MD

K. Czerwenka, MD

S. Leodolter, MD

K. Mayerhofer, MD

Departments of Gynecology and Obstetrics, Anesthesiology, and Gynecopathology, University of Vienna Medical School, Vienna, Austria

Objective: Matrix metalloproteinases (MMPs) have been suggested to play an important role in tumor invasion and metastasis because they degrade a wide range of components of the extracellular matrix. In the present study, we analyzed the expression of MMP-1 and MMP-2 proteins in patients with uterine leiomyosarcoma.

Methods: MMP-1 and MMP-2 expression was investigated by immunohistochemistry from paraffinembedded issue sections in 21 patients with uterine leiomyosarcoma (LMS). The immunohistochemical findings were correlated with different clinicopathologic characteristics of the patients.

Results: MMP-1 was expressed in 86% and MMP-2 was expressed in 48% of uterine LMS. There was a statistically significant positive correlation between vascular space involvement and MMP-2 expression (P = .05) and between age and MMP-2 expression, with patients over 50 years old having significantly more frequent MMp-2-positive tumors than patients younger than 50 years (P = .006). The relationship between MMP-2 expression and tumor stage and recurrence disease did not reach statistical significance. A trend towards prolonged disease-free survival was observed in women with MMP-2-negative LMS compared with patients with MMP-2-positive LMS (P = .09). Furthermore, a univariate analysis revealed that early tumor stage (P = .0001), age at diagnosis less than 50 years (P = .02), and the absence of vascular space involvement (P = .04) were associated with longer overall survival.

Conclusion: The statistically significant positive correlation between MMp-2 expression and vascular space involvement as well as the prolonged disease-free survival rate in patients with MMP-2 negative uterine LMS suggest that MMP-2 plays and important role in tumor invasion and metastasis. Further clinical studies with larger numbers of cases need to be performed to verify these findings.

Key Words: Uterine leiomyosarcoma • MMP-1 and MMP-2 expression • clinicopathologic parameters

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