Journal of the Society for Gynecologic Investigation

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

http://mc.manuscriptcentral.com/rsci

Click here to sign up for SAGE Journal Email Alerts today!

Sign In to gain access to subscriptions and/or personal tools.
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Evans, K. N.
Right arrow Articles by Hewison, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Evans, K. N.
Right arrow Articles by Bulmer, J. N.
Right arrow Articles by Kilby, M. D.
Right arrow Articles by Hewison, M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Journal of the Society for Gynecologic Investigation, Vol. 11, No. 5, 263-271 (2004)
DOI: 10.1016/j.jsgi.2004.02.002

Reviews

Vitamin D and Placental-Decidual Function

Katie N. Evans, BMedSc

Judith N. Bulmer, PhD

Mark D. Kilby, MD

Division of Medical Sciences, Institute of Biomedical Research, The University of Birmingham, Queen Elizabeth Hospital, Birmingham; Department of Pathology, Royal Victoria Infirmary, Queen Victoria Road, Newcastle-upon-Tyne; Department of Fetal Medicine, Birmingham Women's Hospital, Birmingham, United Kingdom

Martin Hewison, PhD

Division of Medical Sciences, Institute of Biomedical Research, The University of Birmingham, Queen Elizabeth Hospital, Birmingham; Department of Pathology, Royal Victoria Infirmary, Queen Victoria Road, Newcastle-upon-Tyne; Department of Fetal Medicine, Birmingham Women's Hospital, Birmingham, United Kingdom; M.Hewison{at}bham.ac.uk

The active form of vitamin D (1,25-dihydroxyvitamin D3, 1,25[OH]2D3) has well-established effects on bone metabolism and mineral homeostasis. However, recently it has become clear that 1,25(OH)2D3 has potent antiproliferative and immunomodulatory actions that are not immediately linked to its role as a skeletal regulator. Both the nuclear receptor for 1,25(OH)2D3 (vitamin D receptor, VDR) and the vitamin D-activating enzyme 1{alpha}-hydroxylase are expressed in a wide variety of nonclassic tissues, highlighting the potential for local autocrine-paracrine responses rather than traditional endocrine effects. Prominent among the tissues that express 1{alpha}-hydroxylase is the placenta-decidua, and this has raised important questions concerning the potential role of locally generated 1,25(OH)2D3 as a modulator of fetal-placental development and function. When bound to the VDR, 1,25(OH)2D3 regulates key target genes associated with implantation, such as HOXA10, whereas the potent immunosuppressive effects of 1,25(OH)2D3 suggest a role in implantation tolerance. These observations are further supported by data from our group showing increased expression of 1{alpha}hydroxylase and VDR in first-trimester trophoblast and decidua from human pregnancies. Studies by other groups have reported abnormal expression of 1{alpha}-hydroxylase in preeclamptic pregnancies, revealing a poential role for 1,25(OH)2D3 as a regulator of placentation. The effect of vitamin D on reproduction has been further endorsed by murine gene knockout models for 1{alpha}-hydroxylase and VDR, both of which are infertile. These observations and other are discussed in this article in which we postulate an active role for 1,25(OH)2D3 in placenta-decidua. In particular, we describe how induction of the vitamin D—activating enzyme 1{alpha}-hydroxylase in early gestation might provide a mechanism by which environmental or dietary vitamin D can influence fetal-placental development.

Key Words: Vitamin D • 1{alpha}-hydroxylase • placenta • decidua • implantation


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Nutr.Home page
L. M. Bodnar, H. N. Simhan, R. W. Powers, M. P. Frank, E. Cooperstein, and J. M. Roberts
High Prevalence of Vitamin D Insufficiency in Black and White Pregnant Women Residing in the Northern United States and Their Neonates
J. Nutr., February 1, 2007; 137(2): 447 - 452.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
K. N. Evans, L. Nguyen, J. Chan, B. A. Innes, J. N. Bulmer, M. D. Kilby, and M. Hewison
Effects of 25-Hydroxyvitamin D3 and 1,25-Dihydroxyvitamin D3 on Cytokine Production by Human Decidual Cells
Biol Reprod, December 1, 2006; 75(6): 816 - 822.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
H. Du, G. S. Daftary, S. I. Lalwani, and H. S. Taylor
Direct Regulation of HOXA10 by 1,25-(OH)2D3 in Human Myelomonocytic Cells and Human Endometrial Stromal Cells
Mol. Endocrinol., September 1, 2005; 19(9): 2222 - 2233.
[Abstract] [Full Text] [PDF]