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The Role of the Anti-Angiogenic Factor Endostatin in Intrauterine Growth Restriction

Neonatal Division, 2nd Department of Obstetrics and Gynecology, University of Athens, 19, Soultani Str., GR-10682 Athens, Greece; malamitsi{at}aias.gr

Theodora Boutsikou, MD

Emmanuel Economou, PhD

Evangelos Makrakis, MD

Zoe Iliodromiti, MD

Evangelia Kouskouni, MD

Demetrios Hassiakos, MD

2nd Department of Obstetrics and Gynecology, University of Athens, Athens, Greece

Objective: To study the impact of intrauterine growth restriction (IUGR) on anti-angiogenesis, by determining and comparing circulating levels of the potent anti-angiogenic factor endostatin, in full-term IUGR (under the 10th customized centile) and appropriate for gestational age (AGA)fetuses, neonates, as well as their mothers, granted that IUGR implies hypoxia and endostatin is down-regulated by the latter.

Methods: In 20 IUGR cases (mainly due to hypertension or preeclampsia) and 20 AGA controls we detenmined circulating endostatin levels, by enzyme immunoassay in the serum of mothers (MS), umbilical cords (UC-mixed arteriovenous blood)-representing the fetal state, and asymptomatic neonates on day 1 (N1) and 4 (N4) of lfe-signifying transition and stabilization to extrauterine life, respectively.

Results: Endostatin levels were significantly higher in AGA than IUGR UC, N1, and N4 (P <. 0000, P = .0006, P = .024, respectively). Furthermore, UC endostatin levels positively correlated with the customized centiles of the infants (Spearman correlation coefficient 0. 69, P = .00001).

Conclusions: IUGR is characterized by lower circulating endostatin concentrations in the fetus and neonate, possibly because under lower oxygen concentrations an unbalanced state of angiogenesis stimulators versus inhibitors takes place.

Key Words: Endostatin • intrauterine growth restriction • preeclampsia • intrauterine hypoxia • angiogenesis

Journal of the Society for Gynecologic Investigation, Vol. 12, No. 3, 195-197 (2005)
DOI: 10.1016/j.jsgi.2005.01.006


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