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Journal of the Society for Gynecologic Investigation
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The Interleukin-6 –174G/C Promoter Polymorphism Is Not Associated With Endometriosis in South Indian Women

Manjula Bhanoori, PhD

Kusuma Arvind Babu, MSc

Mamata Deenadayal, MD

Stephen Kennedy, MD

Centre for Cellular and Molecular Biology; Infertility Institute and Research Centre, Hyderabad, India; Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom

Sisinthy Shivaji, PhD

Centre for Cellular and Molecular Biology; Infertility Institute and Research Centre, Hyderabad, India; Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom; shivas{at}ccmb.res.in

Objective: To investigate the association of the-174 G/C promoter polymorphism of the interleukin-6 (IL-6) gene with endometriosis in South Indian women.

Methods: The genotype frequencies of the common IL-6174 G/C polymorphism were compared in infertility patients with (n = 232) and without (n = 210) endometriosis using polymerase chain reaction (PCR) and sequencing analysis.

Results: The genotype frequencies among the cases and controls were G/G 62.9% and 71.9%, G/C 34. 1% and 25.2%, and C/C 3.0% and 2.9%. The G and C allele frequencies were 80% and 84.6%, and 20% and 15.4%, respectively. There were no statistically signficant differences in the genotype distributions or allele frequencies between the cases and controls (P = .12).

Conclusions: The present study demonstrates no signficant association between the IL-6 -174 G/C promoter polymorphism and endometriosis in South Indian women.

Key Words: Endometriosis • IL-6 promoter • polymorphism

Journal of the Society for Gynecologic Investigation, Vol. 12, No. 5, 365-369 (2005)
DOI: 10.1016/j.jsgi.2005.03.005
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