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Prevalence of Cervical and Intrauterine Human Papillomavirus Infected in the Third Trimester in Asymptomatic Women

Department of Obstetrics and Gynecology; Department of Pathology, University of Vienna Medical School, Vienna General Hospital, Vienna, Austria. Supported by the "Medizinisch-Wissenschaftlicher Fonds des Buergermeisters der Bundeshauptstadt Wien" grant no. 1929; "Jubilaeumsfonds der Oesterreichischen Nationalbank" grant no. 8598 christof.worda{at}meduniwien.ac.at

Ambros Huber, MD

Gernot Hudelist, MD

Christian Schatten, MD

Heinz Leipold, MD

Klaus Czerwenka, MD

Wolfgang Eppel, MD

Department of Obstetrics and Gynecology; Department of Pathology, University of Vienna Medical School, Vienna General Hospital, Vienna, Austria. Supported by the "Medizinisch-Wissenschaftlicher Fonds des Buergermeisters der Bundeshauptstadt Wien" grant no. 1929; "Jubilaeumsfonds der Oesterreichischen Nationalbank" grant no. 8598

Objective: To study the prevalence and association of human papillomavirus (HPV) infection in the cervix of pregnant women without visible signs of genital HPV infection undergoing cesarean delivery in the third trimester and to investigate a possible HPV transmission to the fetus.

Methods: All women underwent cesarean delivery between 37 and 40 weeks of gestation. Cervical samples were taken prior to cesarean delivery. Furthermore, amniotic fluid, placental tissue, and cord blood were sampled and polymerase chain reaction (PCR) or Hybrid Capture II test (Digene Corp, Beltsville, MD) was performed to detect HPV DNA.

Results: We found that 56 (36.6%) of 153 women were positive for HPV in the cervix. Logistic regression analyses showed a decrease of prevalence of HPV infection with increasing maternal age (P = .02). No HPV DNA could be detected in the amniotic fluid or cord blood, whereas eight placental specimens were positive for HPV DNA.

Conclusion: The infection rate in women without clinical symptoms of HPV infection is high, but there was no HPV found in the amniotic fluid and in cord blood in women with subclinical infection in the third trimester.

Key Words: Human papilloma virus • pregnancy • prevalence

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