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Journal of the Society for Gynecologic Investigation
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Decreased Plsma Visfatin Concentrations in Women With Gestational Diabetes Mellitus

Te-Fu Chan, MD

Yi-Ling Chen, BSc

Chien-Hung Lee, PhD

Fan-Hao Chou, PhD

Lee-Chen Wu, BN

Shiang-Bin Jong, BSc

Department of Obstetrics and Gynecology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC; Department of Obstetrics and Gynecology, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung Medical University, Kaohsiung; Department of Nuclear Medicine, Kaohsiung Medical University Hospital, Kaohsiung; Department of Nuclear Medicine, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung Medical University, Kaohsiung; Graduate Institute of Public Health, School of Health Science, Kaohsiung Medical University, Kaohsiung; College of Nursing, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC

Eing-Mei Tsai, MD, PhD

Department of Obstetrics and Gynecology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC; Department of Obstetrics and Gynecology, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung Medical University, Kaohsiung; Department of Nuclear Medicine, Kaohsiung Medical University Hospital, Kaohsiung; Department of Nuclear Medicine, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung Medical University, Kaohsiung; Graduate Institute of Public Health, School of Health Science, Kaohsiung Medical University, Kaohsiung; College of Nursing, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC u9481001{at}kmu.edu.tw

Objective: To test the hypothesis that plasma visfatin concentrations will be lower in women with gestational diabetes mellitus, we evaluated women with gestational diabetes mellitus and healthy pregnant women, and then correlated their plasma visfatin concentrations with body mass index (BMI) and various other parameters.

Methods: A total of 40 women were evaluated: 20 women with gestational diabetes mellitus and 20 healthy pregnant women to serve as control subjects. Plasma visfatin concentrations were analyzed using an enzyme-linked immunosorbent assay.

Results: Plasma visfatin concentrations were significantly lower in the gestational diabetes mellitus group (9.4 ± 3.8 ng/mL) than in the healthy control group (12.6 ± 4.5 ng/mL) (P = .023). A negative correlation was found between plasma visfatin concentrations and maternal (age (r = -0.399, P = .011), first trimester body weight (r = -0.350, P = .027), and first trimster BMI (r = -0.336, P = .034). Multiple linear regression analysis revealed that maternal age (P = .017) and gestational diabetes mellitus/no gestational diabetes mellitus (P = .044) were independently related to plasma visfatin concentrations. However, no relationship was found with either gestational age at the time of sampling or first trimester BMI.

Conclusions: Our results show that there are decreased concentrations of plasma visfatin in gestational diabetes mellitus subjects and this may indicate that visfatin plays a role in the pathogenesis of gestational diabetes mellitus. However, further experiments are needed to clarify this role.

Key Words: Visfatin • gestational diabetes mellitus • body mass index

Journal of the Society for Gynecologic Investigation, Vol. 13, No. 5, 364-367 (2006)
DOI: 10.1016/j.jsgi.2006.04.007
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