Journal of the Society for Gynecologic Investigation

 

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Journal of the Society for Gynecologic Investigation, Vol. 13, No. 6, 430-434 (2006)
DOI: 10.1016/j.jsgi.2006.05.008

Vaginal Matrix Metalloproteinase Levels in Pregnant Women With Bacterial Vaginosis

Laura Diaz-Cueto, MD, PhD

Adrian Cuica-Flores, MD

Francisco Ziga-Cordero, MD

Jose Antonio Ayala-Mendez, MD

Gilberto Tena-Alavez, MD

Pablo Dominguez-Lopez, MSc

Rocio Cuevas-Antonio, BSc

Research Unit in Reproductive Medicine, Teaching and Research Program, and Maternal-Fetal Medicine Department, UMAE en Ginecologia y Obstetricia "Luis Castelazo Ayala," Instituto Mexicano del Seguro Social, Mexico D F, Mexico

Fabian Arechavaleta-Velasco, PhD

Unidad de Investigacion Medica en Medicina Reproductiva, UMAE en Ginecologia y Obstetricia, IMSS, Apartado Postal 99-065, Unidad Independencia, 10101 México D. F. fabianj{at}servidor.unam.mx

Objective: To compare matrix metalloproteinase (MMP)-8 and MMP-9 levels in the vaginal secretions of pregnant women with or without asymptomatic bacterial vaginosis (BV).

Methods: In this study, vaginal levels and molecular forms of MMP-8 and MMP-9 were studied in 36 pregnant women between 28 and 34 weeks of gestation with asymptomatic BV and 41 pregnant women, matched for gestational age, without BV.

Results: Vaginal MMP-8 concentrations were significantly higher (P = .023) in BV-positive women. There was no significant difference in MMP-9 levels between healthy pregnant controls and BV-positive pregnant women. The presence of MMP-8 was confirmed by a 38-kd band on Western blots.

Conclusions: Our findings show that BV is associated with increased levels of MMP-8 in vaginal fluid. Increased production of collagen-degrading enzymes such as MMP-8 is a possible causeof spontaneous spreterm delivery in pregnant women with asymptomatic BV.

Key Words: Bacterial vaginosis • matrix metalloproteinases • pregnancy


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