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Serum Cystatin C in Pregnancies With Normal and Restricted Fetal Growth

Neonatal Division, Second Department of Obstetrics and Gynecology, Athens University Medical School,Athens, Greece; 19, Soultani Street, 10682 Athens, Greece; amalpu{at}aretaieio.uoa.grmalamitsi{at}aias.gr

Despina D. Briana, MD

Louiza Kontara, MD

Maria Boutsikou, MD

Stavroula Baka, MD

Demetrios Hassiakos, MD

Neonatal Division, Second Department of Obstetrics and Gynecology, Athens University Medical School,Athens, Greece

Antonios Marmarinos, PhD

Demetrios Gourgiotis, PhD

Research Laboratories, Second Department of Pediatrics, Athens University Medical School,Athens, Greece

The objective of this study was to investigate circulating levels of cystatin C (an important endogenous marker of renal function) in mothers, fetuses, and neonates from intrauterine growth–restricted (IUGR; characterized by impaired nephrogenesis) and appropriate-for-gestational-age (AGA) pregnancies. Serum cystatin C levels were measured by enzyme immunoassay in 40 parturients and their 20 IUGR (3rd customized centile, due to gestational pathology) and 20 AGA fetuses and neonates on postnatal day 1 (N1) and 4 (N4). Comparatively, creatinine and urea concentrations were determined in the same samples. Fetal cystatin C levels were higher in the AGA than the IUGR group (P = .001). In both groups, maternal cystatin C levels were lower than fetal (P < .001), N1 (P < .001), and N4 (P < .001) levels. Fetal levels were higher than N1 (P < .001) and N4 (P < .001), and N1 levels were higher than N4 (P = .007) ones. In both groups, no correlation existed between maternal and fetal levels, but positive correlations were found between cystatin C, creatinine, and urea levels in maternal and neonatal samples (in all cases, r 0.376 and P .045). Cystatin C levels did not correlate with gestational age and did not differ between males and females. Fetal cystatin C serum levels are lower in the IUGR group, significantly decrease after birth, and do not correlate with maternal levels in both groups. In addition, serum cystatin C levels positively correlate with respective creatinine and urea levels in the perinatal period.

Key Words: Cystatin C • glomerular filtration rate • fetus • neonate • intrauterine growth restriction

Reproductive Sciences, Vol. 14, No. 1, 37-42 (2007)
DOI: 10.1177/1933719106298196


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