This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Chan, T.-F. Articles by Tsai, E.-M. Search for Related Content PubMed PubMed Citation Articles by Chan, T.-F. Articles by Chen, H.-S. Articles by Chen, Y.-C. Articles by Lee, C.-H. Articles by Chou, F.-H. Articles by Chen, I-J. Articles by Chen, S.-Y. Articles by Jong, S.-B. Articles by Tsai, E.-M. Social Bookmarking                   What's this?

Increased Serum Retinol-Binding Protein 4 Concentrations in Women With Gestational Diabetes Mellitus

Department of Obstetrics and Gynecology, Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University Hospital, Department of Obstetrics and Gynecology, Kaohsiung Medical University Hospital

Hung-Sheng Chen, MD

Department of Obstetrics and Gynecology, Kaohsiung Medical University Hospital

Yu-Chieh Chen, MD

Department of Obstetrics and Gynecology, Kaohsiung Medical University Hospital

Chien-Hung Lee, PhD

Graduate Institute of Public Health, School of Health Science, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China

Fan-Hao Chou, PhD

College of Nursing, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China

I-Ju Chen, BSc

Department of Nuclear Medicine, Kaohsiung Medical University Hospital

Su-Yin Chen, BSc

Department of Nuclear Medicine, Kaohsiung Medical University Hospital

Shiang-Bin Jong, PhD

Department of Nuclear Medicine, Kaohsiung Medical University Hospital

Eing-Mei Tsai, MD, PhD

Department of Obstetrics and Gynecology, Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University Hospital, Department of Obstetrics and Gynecology, Kaohsiung Medical University Hospital, u9481001{at}kmu.edu.tw

The authors hypothesized that serum retinol-binding protein 4 (RBP4) concentrations will be higher in gestational diabetes mellitus (GDM) subjects. This study tested both women with GDM and healthy pregnant women and correlated their serum RBP4 concentrations with body mass index (BMI) and a variety of other parameters. Also, since there is no information on the relationship between RBP4 concentrations in maternal and fetal serum, this study measured these at delivery and examined whether there were correlations between the cord serum RBP4 levels and maternal serum RBP4 concentrations, neonatal birth weights, and gestational age at delivery. A total of 40 women were evaluated: 20 women with GDM and 20 healthy pregnant women to serve as control subjects. Serum RBP4 concentrations were analyzed with the use of an enzyme-linked immunosorbent assay kit. Serum RBP4 concentrations at glucose challenge test (GCT) were significantly higher in the GDM group (42.4 ± 13.8 ng/mL) than in the healthy control group (32.0 ± 8.7 ng/mL; P = .007). BMI at GCT (P = .003) and GDM/no GDM (P = .014) were significantly correlated to serum RBP4 concentrations at GCT by multiple linear regression analysis. In GDM subjects, serum RBP4 concentrations immediately after delivery were significantly lower than those at GCT (30.1 ± 11.0 ng/mL, 42.4 ± 13.8 ng/mL; P < .001), but there was no such difference in normal subjects (30.9 ± 10.0 ng/mL, 32.0 ± 8.7 ng/mL; P = .581). Cord serum RBP4 concentrations were significantly lower than maternal serum RBP4 concentrations at delivery (10.9 ± 3.8 ng/mL, 30.5 ± 10.4 ng/mL; P < .001). Only fetal birth weight (P = .049) was independently related to cord serum RBP4 concentrations at delivery by multiple linear regression analysis. This study found increased serum RBP4 concentrations at GCT in GDM subjects, and GDM was significantly correlated to serum RBP4 levels after adjustment for the effect of BMI. Lower RBP4 concentrations were found at delivery in GDM subjects. Maternal serum RBP4 concentrations were significantly higher than cord serum RBP4 concentrations, and fetal birth weights were independently correlated to cord serum RBP4 concentrations. These findings may indicate that RBP4 plays a role in the pathogenesis of GDM. However, further experiments are required to clarify this role and find a possible regimen for GDM treatment.

Key Words: RBP4 • GDM • BMI • fetal birth weights

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				J. P. Mills, H. C. Furr, and S. A. Tanumihardjo Retinol to Retinol-Binding Protein (RBP) Is Low in Obese Adults due to Elevated apo-RBP Experimental Biology and Medicine, October 1, 2008; 233(10): 1255 - 1261. [Abstract] [Full Text] [PDF]

				S. H. Choi, S. H. Kwak, B.-S. Youn, S. Lim, Y. J. Park, H. Lee, N. Lee, Y. M. Cho, H. K. Lee, Y.-B. Kim, et al. High Plasma Retinol Binding Protein-4 and Low Plasma Adiponectin Concentrations Are Associated with Severity of Glucose Intolerance in Women with Previous Gestational Diabetes Mellitus J. Clin. Endocrinol. Metab., August 1, 2008; 93(8): 3142 - 3148. [Abstract] [Full Text] [PDF]

				T Ueland, T Dalsoren, N Voldner, K Godang, T Henriksen, and J Bollerslev Retinol-binding protein-4 is not strongly associated with insulin sensitivity in normal pregnancies. Eur. J. Endocrinol., July 1, 2008; 159(1): 49 - 54. [Abstract] [Full Text] [PDF]