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Reproductive Sciences, Vol. 14, No. 3, 246-252 (2007)
DOI: 10.1177/1933719107300871

The Effects of Bumetanide on Human Umbilical Artery Contractions

Emel Dayioglu, MS

Department of Pharmacology, Faculty of Pharmacy, Gazi University, Ankara, Turkey

C. Kemal Buharalioglu, PhD

Department of Pharmacology, Faculty of Pharmacy, Mersin University, Mersin, Turkey

Ferit Saracoglu, MD

Department of Obstetrics and Gynecology, Ankara Numune Education and Research Hospital, Ankara, Turkey

Fatma Akar, PhD

Department of Pharmacology, Faculty of Pharmacy, Gazi University, Ankara, Turkey, fakar{at}gazi.edu.t

The authors investigate the effect of bumetan ide, an inhibitor of NKCC1 and a loop diuretic, on the tone of human umbilical artery (HUA). Rings of HUA (n = 35) from vaginal deliveries were suspended for isometric tension recordings in organ baths. Cumulative concentration-response curves to serotonin, histamine, and KCl were performed in the absence (control) or in the presence of bumetanide. The relaxant effect of bumetanide was also evaluated in serotonin- and histamine-induced contractions. Bumetanide inhibited HUA tone in serotonin- and histamine-induced contractions with significant changes in the potency (pD2) and maximum contractile response (Emax) values. However, only pD 2 values for KCl-induced contraction significantly changed in the presence of bumetanide. Bumetanide caused concentration-dependent and sustained relaxations in serotonin-induced contraction; however, there was refractoriness in histamine-induced contraction. These findings raise the possibility that NKCC1 may play a role in the regulation of the umbilical artery tone.

Key Words: Bumetanide • human umbilical artery • serotonin • histamine.


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