Reproductive Sciences

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Register here to gain access to SAGE's 500+ Journals Online

Click here to sign up for SAGE Journal Email Alerts today!

Sign In to gain access to subscriptions and/or personal tools.
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via ISI Web of Science (1)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Petropoulos, S.
Right arrow Articles by Matthews, S. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Petropoulos, S.
Right arrow Articles by Kalabis, G. M.
Right arrow Articles by Gibb, W.
Right arrow Articles by Matthews, S. G.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Reproductive Sciences, Vol. 14, No. 4, 321-328 (2007)
DOI: 10.1177/1933719107303856

Functional Changes of Mouse Placental Multidrug Resistance Phosphoglycoprotein (ABCB1) With Advancing Gestation and Regulation by Progesterone

Sophie Petropoulos, HBMSc

Departments of Physiology, Obstetrics and Gynaecology, and Medicine, University of Toronto, Departments of Obstetrics and Gynaecology, Cellular and Molecular Medicine, University of Ottawa

Grazyna M. Kalabis, PhD

Departments of Physiology, Obstetrics and Gynaecology, and Medicine, University of Toronto, Departments of Obstetrics and Gynaecology, Cellular and Molecular Medicine, University of Ottawa

William Gibb, PhD

Departments of Physiology, Obstetrics and Gynaecology, and Medicine, University of Toronto, Departments of Obstetrics and Gynaecology, Cellular and Molecular Medicine, University of Ottawa

Stephen G. Matthews, PhD

Department of Physiology, Faculty of Medicine, University of Toronto, stephen.matthews{at}utoronto.ca

Multidrug resistance phosphoglycoprotein (ABCB1) has been shown to limit maternal-fetal transfer by actively excluding ABCB1 substrates. The authors have previously demonstrated a marked decrease in placental ABCB1 expression in the human and mouse with advancing gestation. In the present study, it is hypothesized that the decrease in ABCB1 expression will result in increased transplacental transfer of ABCB1 substrates over the second half of gestation and that progesterone exhibits a regulatory role on placental ABCB1 expression and function. The authors demonstrate a significant increase in transplacental transfer of [3H]digoxin (an ABCB1 substrate) in late gestation (E18.5; P < .001) when compared to earlier embryonic days. Furthermore, maternal plasma progesterone levels did not influence expression or function of ABCB1. The authors conclude that the fetus is increasingly exposed to both endogenous and exogenous substrates of ABCB1 present in the maternal circulation with advancing gestation and that progesterone does not elicit a regulatory role on placental ABCB1 expression or function in vivo.

Key Words: Multidrug resistance • transplacental transfer • mouse • [3H]digoxin • progesterone.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?