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Reproductive Sciences, Vol. 14, No. 5,
486-497 (2007)
DOI: 10.1177/1933719107304565
Relative Expression of 1,25-Dihydroxyvitamin D3 Receptor, Vitamin D 1 -Hydroxylase, Vitamin D 24-Hydroxylase, and Vitamin D 25-Hydroxylase in Endometriosis and Gynecologic Cancers
Admir Agic, MD
Department of Gynecology and Obstetrics, University of Schleswig-Holstein
Hong Xu, MD
Department of Gynecology and Obstetrics, University of Schleswig-Holstein
Christopher Altgassen, MD, PhD
Department of Gynecology and Obstetrics, University of Schleswig-Holstein
Frank Noack, MD
Department of Pathology University of Schleswig-Holstein, Lübeck, Germany
Monika M. Wolfler, MD
Department of Gynecology and Obstetrics, Aachen, Germany
Klaus Diedrich, MD, PhD
Department of Gynecology and Obstetrics, University of Schleswig-Holstein
Michael Friedrich, MD, PhD
Department of Gynecology and Obstetrics, University of Schleswig-Holstein
Robert N. Taylor, MD, PhD
Department of Gynecology and Obstetrics, Emory University, Atlanta, Georgia
Daniela Hornung, MD, PhD
Department of Gynecology and Obstetrics, University of Schleswig-Holstein, d.hornung{at}gmx.de
The authors demonstrate expression of the vitamin D receptor (VDR) and its hydroxylases in the endometrium and ovaries of women with and without endometriosis and endometrial or ovarian cancer. Immunohistochemistry showed strong staining of the VDR in endometriosis and endometrial cancer, with the most intense staining in epithelial cells. The VDR mRNA was significantly increased in patients with endometrial and ovarian cancer compared to the control group. There was a significantly higher 1 -hydroxylase expression in the endometrium of patients with endometriosis compared to healthy controls. The observed differences in VDR and 1 -hydroxylase mRNA levels were maintained at the protein level. The authors found no differences in 25-OH vitamin D levels between the serum of patients with endometriosis (25.7 ± 2.1 ng/mL, n = 46) and healthy controls (22.6 ± 2.0 ng/mL, n = 33, P = .31). They hypothesize that vitamin D might influence the local activity of immune cells and cytokines thought to play important pathogenic roles in the development and maintenance of endometriosis.
Key Words: Endometriosis gynecologic cancer vitamin D hydroxylases.

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