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Review Article: Preeclampsia—A Pressing Problem: An Executive Summary of a National Institute of Child Health and Human Development Workshop

Pregnancy and Perinatology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, ilekisj{at}mail.nih.gov

Uma M. Reddy, MD, MPH

Magee-Womens Research Institute and Department of Obstetrics Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania

James M. Roberts, MD

Magee-Womens Research Institute and Department of Obstetrics Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania

On September 21 and 22, 2006, the National Institute of Child Health and Human Development of the National Institutes of Health sponsored a 2-day workshop titled "Preeclampsia—A Pressing Problem." The purpose of the workshop was to bring together leaders in the field to present and discuss their diverse research areas, which ranged from basic science to clinical trials and management, and to identify scientific gaps. This article is a summary of the proceedings of that workshop. Although much progress is being made in understanding the underpinnings of preeclampsia, a number of research gaps are identified that, if filled, would hasten progress in the field. It is the overall consensus that preeclampsia is a multifactorial disease whose pathogenesis is not solely vascular, genetic, immunologic, or environmental but a complex combination of factors. In addition, a number of specific scientific gaps are identified including insufficient multidisciplinary and collaborative research, clinical trials and studies of patient management, and a lack of in-depth mechanistic research. The research community needs to focus on these gaps to better understand the disease, with the ultimate goal of preventing the disorder.

Key Words: Preeclampsia • workshop • research • trials • gaps.

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