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Reproductive Sciences
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Maternal Caffeine Administration and Cerebral Oxygenation in Near-Term Fetal Sheep

Takuji Tomimatsu

Center for Perinatal Biology, Departments of Physiology and Obstetrics & Gynecology, School of Medicine, Loma Linda University, Loma Linda, California

Stephen J. Lee

Center for Perinatal Biology, Departments of Physiology and Obstetrics & Gynecology, School of Medicine, Loma Linda University, Loma Linda, California

Jorge Pereyra Peña

Center for Perinatal Biology, Departments of Physiology and Obstetrics & Gynecology, School of Medicine, Loma Linda University, Loma Linda, California

Jonathon M. Ross

Center for Perinatal Biology, Departments of Physiology and Obstetrics & Gynecology, School of Medicine, Loma Linda University, Loma Linda, California

Jordan A. Lang

Center for Perinatal Biology, Departments of Physiology and Obstetrics & Gynecology, School of Medicine, Loma Linda University, Loma Linda, California

Lawrence D. Longo

Center for Perinatal Biology, Departments of Physiology and Obstetrics & Gynecology, School of Medicine, Loma Linda University, Loma Linda, California

The authors test the null hypothesis that maternal caffeine administration will not significantly alter fetal cerebral oxygenation. The authors measured fetal arterial blood gases, cortical tissue O2 tension (tPO2), sagittal sinus blood gases, and laser Doppler cerebral blood flow in response to a 30-minute caffeine infusion (400 mg intravenously) into 7 near-term pregnant ewes, and they calculated fractional O2 extraction and relative cerebral metabolic rate for O2 (CMRO2). Following maternal caffeine infusion, both fetal cortical tPO2 and sagittal sinus (HbO2) decreased significantly, from 10.7 ± 0.9 to 6.8 ± 1.1 Torr and from 46% ± 2% to 37% ± 6%, respectively. This was associated with significant 20% to 30% increases in fractional O2 extraction and CMRO 2. Fetal arterial blood gas values did not change significantly. In conclusion, maternal caffeine administration significantly decreases cerebral oxygenation without affecting systemic oxygenation in fetal sheep. The authors speculate that for a fetus that may be otherwise compromised, this increase in CMRO2 with decreased cortical tPO2 could present a problem.

Key Words: Caffeine • fetal sheep • cerebral blood flow • cerebral metabolic rate for O2.

Reproductive Sciences, Vol. 14, No. 6, 588-594 (2007)
DOI: 10.1177/1933719107307717
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