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Neuroprotective Effect of Long-term MgSO4 Administration After Cerebral Hypoxia-Ischemia in Newborn Rats Is Related to the Severity of Brain Damage

Department of Physiology and Pharmacology Faculty of Medicine, Aristotle University of Thessaloniki Thessaloniki, Greece, spandou{at}med.auth.gr

Vassiliki Soubasi, MD, PhD

Department of Neonatology Facuty of Medicine, Aristotle University of Thessaloniki Thessaloniki Greece

Stamatia Papoutsopoulou, PhD

Department of Physiology and Pharmacology Faculty of Medicine, Aristotle University of Thessaloniki Thessaloniki, Greece

Persefoni Augoustides-Savvopoulou, MD, PhD

Department of Pediatrics Faculty of Medcine, Aristotle University of Thessloniki, Thessloniki, Greece

Theodoros Loizidis, MD, PhD

Department of Physiology and Pharmacology Faculty of Medicine, Aristotle University of Thessaloniki Thessaloniki, Greece

Anastasia Pazaiti, MD, PhD

Department of Physiology and Pharmacology Faculty of Medicine, Aristotle University of Thessaloniki Thessaloniki, Greece

George Karkavelas, MD, PhD

Department of Pathology Faculty of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece

Olympia Guiba-Tziampiri, MD, PhD

Department of Physiology and Pharmacology Faculty of Medicine, Aristotle University of Thessaloniki Thessaloniki, Greece

Previous studies have shown contradictory results regarding magnesium-mediated neuroprotection in animal models of perinatal asphyxia. The aim of this study is to investigate the e fects of MgSO₄ postasphyxial treatment on hypoxia-ischemia (HI)—induced brain injury in neonatal rats and the possibility that this e fect is related to the severity of brain damage. Seven-day-old rats underwent unilateral carotid artery ligation followed by 1 or 2 hours of hypoxia (8% O₂) and MgSO₄ administration. Adenosine triphosphate/phosphocreatine and glutamate/glutamine measurements and neuropathological evaluation of the hippocampus were used to assess the e fects of HI and MgSO₄. HI caused time-dependent changes in energy stores, amino acid concentrations, and brain damage. Administration of MgSO₄ after 1 hour but not after 2 hours of hypoxia resulted in significant prevention of HI-induced brain injury. MgSO₄ administration results in a significant protection against moderate HI-induced brain damage, whereas it fails to offer a similar effect against severe brain damage.

Key Words: Magnesium sulfate • hypoxia-ischemia • newborn rat • hippocampus.

Reproductive Sciences, Vol. 14, No. 7, 667-677 (2007)
DOI: 10.1177/1933719107305864


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