This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Lommerse, T. Articles by Peeters, L. L. Search for Related Content PubMed PubMed Citation Social Bookmarking                   What's this?

Endothelium-Dependent Vasodilatation in Formerly Preeclamptic Women Correlates Inversely With Body Mass Index and Varies Independently of Plasma Volume

Department of Obstetrics and Gynecology, University of Maastricht, Maatricht, The Netherlands

Robert Aardenburg, MD

Department of Obstetrics and Gynecology, University of Maastricht, Maatricht, The Netherlands, robert{at}aardenburg.org

Alphons Houben, PhD

Department of Internal Medicine, University of Maastricht, Maastricht, The Netherlands

Louis L. Peeters, MD, PhD

Department of Obstetrics and Gynecology, University of Maastricht, Maatricht, The Netherlands

Endothelial dysfunction and a subnormal plasma volume predispose to preeclampsia. The authors determine whether endothelium-dependent vasodilatation is lower in formerly preeclamptic women, explore whether endothelial dysfunction coincides with low plasma volume, and determine if endothelial dysfunction correlates with circulating endothelial stressors. In formerly preeclamptic women and controls, the authors estimated changes in forearm blood flow after arterial occlusion. They measured plasma volume, blood pressure, and circulating variables. To identify factors associated with endothelial function, the authors used Spearman correlation and regression analysis. Endothelial function did not differ between patients and controls and did not correlate with plasma volume; however, it did correlate negatively with body mass index and positively with arterial compliance. Analysis suggested a negative impact of metabolic syndrome on endothelial function. In formerly preeclamptic women, endothelial function is comparable to controls and varies independently of plasma volume. In patients, endothelial function does vary with features of the metabolic syndrome.

Key Words: Preeclampsia • plasma volume • endothelial function.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?