This Article Free Full Text (Free PDF) Free References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Gold, E. B. Articles by Greendale, G. A. Search for Related Content PubMed PubMed Citation Articles by Gold, E. B. Articles by Lasley, B. Articles by Crawford, S. L. Articles by McConnell, D. Articles by Joffe, H. Articles by Greendale, G. A. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Hazardous Substances DB MENOTROPINS Social Bookmarking                         What's this?

Relation of Daily Urinary Hormone Patterns to Vasomotor Symptoms in a Racially/Ethnically Diverse Sample of Midlife Women: Study of Women's Health Across the Nation

Division of Epidemiology, Department of Public Health Sciences, School of Medicine, University of California, Davis, ebgold{at}ucdavis.edu

Bill Lasley, PhD

Center for Health and the Environment, University of California, Davis

Sybil L. Crawford, PhD

Department of Medicine, University of Massachusetts Medical School, Worcester

Dan McConnell, PhD

Reproductive Sciences Program, University of Michigan, Ann Arbor

Hadine Joffe, MD

Perinatal and Reproductive Psychiatry Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Cambridge, Massachusetts

Gail A. Greendale, MD

Division of Geriatrics, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles

The associations of urinary pregnanediol-glucuronide (PdG) levels and menstrual bleeding and their modification of associations of other risk factors with vasomotor symptoms (VMS) are examined. Daily urine samples were collected for 1 menstrual cycle or 50 days if no bleeding occurred. Participants (n = 742) were aged 43 to 54 years, not using exogenous hormones, not pregnant, had an intact uterus and > 1 ovary, and menstruated in the prior 3 months. Multivariate analyses were performed of urinary hormone metabolites and within-woman proportion of days reporting VMS. VMS reporting was 4-fold greater (P = .0005) in women whose urine collections ended without bleeding. In collections with PdG levels suggestive of ovulatory activity according to the work of Kassam et al, VMS are significantly associated with obesity, early perimenopause, and increasing PdG levels. In collections with lower PdG concentrations, VMS are significantly increased with no bleeding, smoking, higher age, physical activity, follicle-stimulating hormone, and luteinizing hormone and are significantly reduced with increasing estrogen concentrations.

Key Words: Menopause • endogenous hormones • hot flashes • smoking • body weight • race/ethnicity • socioeconomic status • ovarian function.

Reproductive Sciences, Vol. 14, No. 8, 786-797 (2007)
DOI: 10.1177/1933719107308613


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?