Reproductive Sciences

 

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Reproductive Sciences, Vol. 14, No. 8 suppl, 6-10 (2007)
DOI: 10.1177/1933719107309818

The Role of the Extracellular Matrix in Ovarian Follicle Development

Teresa K. Woodruff, PhD

Department of Obstetrics and Gynecology, Feinberg School of Medicine, The Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, Department of Chemical and Biological Engineering, McCormick School of Engineering, The Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, tkw{at}northwestern.edu

Lonnie D. Shea, PhD

Department of Obstetrics and Gynecology, Feinberg School of Medicine, The Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, Department of Chemical and Biological Engineering, McCormick School of Engineering, The Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois

Regulation of ovarian follicle development depends on endocrine- and paracrine-acting hormones, the 3-dimensional architecture of the follicle, and the physical rigidity of the surrounding tissue. These 3 forces are integrated throughout the life cycle of the follicle to ensure appropriate hormone secretion, differentiation of the somatic cells, and maturation of the oocyte. The process of in-follicle maturation provides a new tool for understanding ovarian follicle development under the influence of these factors.

Key Words: Follicle • alginate • in-follicle maturation.


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