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Reproductive Sciences
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Genes in Glucose Metabolism and Association With Spina Bifida

Christina M. Davidson, MD

Department of Obstetrics, Gynecology and Reproductive Sciences University of Texas Medical School at Houston

Hope Northrup, MD

Department of Pediatrics University of Texas Medical School at Houston

Terri M. King, PhD

Department of Pediatrics University of Texas Medical School at Houston

Jack M. Fletcher, PhD

Department of Psychology, University of Houston,Texas

Irene Townsend, RN

Shriners Hospital for Children, Houston,Texas

Gayle H. Tyerman, MD

Shriners Hospital for Children, Los Angeles, California

Kit Sing Au, PhD

Department of Obstetrics, Gynecology and Reproductive Sciences University of Texas Medical School at Houston, kit-sing.au@uth .tmc.edu

The authors test single nucleotide polymorphisms (SNPs) in coding sequences of 12 candidate genes involved in glucose metabolism and obesity for associations with spina bifida. Genotyping was performed on 507 children with spina bifida and their parents plus anonymous control DNAs from Hispanic and Caucasian individuals. The transmission disequilibrium test was performed to test for genetic associations between transmission of alleles and spina bifida in the offspring (P < .05). A statistically significant association between Lys481 of HK1 (G allele), Arg109Lys of LEPR (G allele), and Pro196 of GLUT1 (A allele) was found ( P = .019, .039, and .040, respectively). Three SNPs on 3 genes involved with glucose metabolism and obesity may be associated with increased susceptibility to spina bifida.

Key Words: Spina bifida • glucose metabolism • obesity • single nucleotide polymorphism.

Reproductive Sciences, Vol. 15, No. 1, 51-58 (2008)
DOI: 10.1177/1933719107309590
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