Reproductive Sciences

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

http://mc.manuscriptcentral.com/rsci

SAGETRACK

Sign In to gain access to subscriptions and/or personal tools.
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (1)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Davidson, C. M.
Right arrow Articles by Kit Sing Au,
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Reproductive Sciences, Vol. 15, No. 1, 51-58 (2008)
DOI: 10.1177/1933719107309590
© 2008 SAGE Publications

Genes in Glucose Metabolism and Association With Spina Bifida

Christina M. Davidson, MD

Department of Obstetrics, Gynecology and Reproductive Sciences University of Texas Medical School at Houston

Hope Northrup, MD

Department of Pediatrics University of Texas Medical School at Houston

Terri M. King, PhD

Department of Pediatrics University of Texas Medical School at Houston

Jack M. Fletcher, PhD

Department of Psychology, University of Houston,Texas

Irene Townsend, RN

Shriners Hospital for Children, Houston,Texas

Gayle H. Tyerman, MD

Shriners Hospital for Children, Los Angeles, California

Kit Sing Au, PhD

Department of Obstetrics, Gynecology and Reproductive Sciences University of Texas Medical School at Houston, kit-sing.au@uth .tmc.edu

The authors test single nucleotide polymorphisms (SNPs) in coding sequences of 12 candidate genes involved in glucose metabolism and obesity for associations with spina bifida. Genotyping was performed on 507 children with spina bifida and their parents plus anonymous control DNAs from Hispanic and Caucasian individuals. The transmission disequilibrium test was performed to test for genetic associations between transmission of alleles and spina bifida in the offspring (P < .05). A statistically significant association between Lys481 of HK1 (G allele), Arg109Lys of LEPR (G allele), and Pro196 of GLUT1 (A allele) was found ( P = .019, .039, and .040, respectively). Three SNPs on 3 genes involved with glucose metabolism and obesity may be associated with increased susceptibility to spina bifida.

Key Words: Spina bifida • glucose metabolism • obesity • single nucleotide polymorphism.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Reproductive SciencesHome page
E. A. Reece
Review Article: In the Search for Genes Responsible for Neural Tube Defects, Glucose Metabolism Matters
Reproductive Sciences, January 1, 2008; 15(1): 7 - 8.
[PDF]