Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here to register

Click here to sign up for SAGE Journal Email Alerts today!

Sign In to gain access to subscriptions and/or personal tools.
Reproductive Sciences
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Mendoza, N.
Right arrow Articles by Ruiz, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mendoza, N.
Right arrow Articles by Morón, F. J.
Right arrow Articles by Quereda, F.
Right arrow Articles by Vázquez, F.
Right arrow Articles by Rivero, M. C.
Right arrow Articles by Martínez-Astorquiza, T.
Right arrow Articles by Real, L. M.
Right arrow Articles by Sánchez-Borrego, R.
Right arrow Articles by González-Pérez, A.
Right arrow Articles by Ruiz, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

A Digenic Combination of Polymorphisms Within ESR1 and ESR2 Genes Are Associated With Age at Menarche in the Spanish Population

Nicolás Mendoza, MD, PhD

Servicio de Ginecología y Obstetricia, Hospital Universitario Virgen de las Nieves, Granada, Spain

Francisco Jesús Morón, MS

Departamento de Genómica Estructural, Neocodex,Avda, Charles Darwin n'6,Acc.A. Parque Tecnológico Isla de la Cartuja, Sevilla, Spain

Francisco Quereda, MD, PhD

Servicio de Ginecología y Obstetricia, Hospital San Juan de Alicante, Alicante, Spain

Francisco Vázquez, MD, PhD

CEOGA, Clínica de Ginecología, Lugo, Spain

Mari C. Rivero

Departamento de Genómica Estructural, Neocodex,Avda, Charles Darwin n'6,Acc.A. Parque Tecnológico Isla de la Cartuja, Sevilla, Spain

Txantón Martínez-Astorquiza, MD, PhD

Servicio de Ginecología, Clínica Sanatorio Bilbaíno, Bilbao, Spain

Luis M. Real, PhD

Departamento de Genómica Estructural, Neocodex,Avda, Charles Darwin n'6,Acc.A. Parque Tecnológico Isla de la Cartuja, Sevilla, Spain

Rafael Sánchez-Borrego, MD, PhD

Clínica Diatros, Gavá, Barcelona, Spain

Antonio González-Pérez, MS

Departamento de Genómica Estructural, Neocodex,Avda, Charles Darwin n'6,Acc.A. Parque Tecnológico Isla de la Cartuja, Sevilla, Spain

Agustín Ruiz, MD, PhD

Departamento de Genómica Estructural, Neocodex,Avda, Charles Darwin n'6,Acc.A. Parque Tecnológico Isla de la Cartuja, Sevilla, Spain, aruiz{at}neocodex.es

In the present study, the authors look at an association of genetic variants within estrogen synthesis and signaling pathways and age at menarche (AAM) in Spanish women. They analyzed 9 polymorphisms in 6 different genes in 714 well-characterized postmenopausal women from Spain. They performed a quantitative trait locus study of these markers individually or in digenic combinations in relation to AAM. None of the studied markers, with the exception of the follicle-stimulating hormone receptor (P = .013), were significantly associated with AAM in the Spanish population, and no marker demonstrated an association of statistical significance after multiple testing corrections ( P > .0055). In contrast, linear regression analysis suggests epistatic interactions including ESR1 and ESR2 loci in relation to AAM in the series (P = .003). The results suggest that epistatic interactions of ESR1 and ESR2 alleles could be associated with advancing AAM among Spanish women.

Key Words: Menarche • SNPs • association studies • complex traits • epistatic interaction.

Reproductive Sciences, Vol. 15, No. 3, 305-311 (2008)
DOI: 10.1177/1933719107314064
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?