Reproductive Sciences

 

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Reproductive Sciences, Vol. 15, No. 6, 598-603 (2008)
DOI: 10.1177/1933719108316910

Thyroid Hormone Regulates Renocortical COX-2 and PGE2 Expression in the Late Gestation Fetal Sheep

Luke C. Carey, PhD

Departments of Obstetrics and Gynecology, Wake Forest University School of Medicine, Center of Research for Obstetrics and Gynecology, Forest University School of Medicine, Winston-Salem, North Carolina, lcarey{at}wfubmc.edu

Nancy K. Valego, PhD

Departments of Obstetrics and Gynecology, Wake Forest University School of Medicine, Center of Research for Obstetrics and Gynecology, Forest University School of Medicine, Winston-Salem, North Carolina

Kai Chen, MD

Departments of Obstetrics and Gynecology, Wake Forest University School of Medicine, Center of Research for Obstetrics and Gynecology, Forest University School of Medicine, Winston-Salem, North Carolina

James C. Rose, PhD

Departments of Obstetrics and Gynecology, Wake Forest University School of Medicine, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Center of Research for Obstetrics and Gynecology, Forest University School of Medicine, Winston-Salem, North Carolina

Cyclooxygenase 2 (COX-2) is important for development of the fetal kidney. Precisely how renal COX-2 expression is regulated in fetal life is unclear. The hypothesis that thyroid hormone positively regulates COX-2 and PGE2 levels in the late gestation fetal kidney cortex was tested. Sham, thyroidectomized (TX), and TX + thyroid hormone replacement (R) fetal sheep were studied. TX was performed at 120 days gestational age (dGA). TX + R fetuses were continuously infused with thyroxine from 3 days after surgery until study completion. Fetal kidney cortex was obtained at 137 dGA for measurement of renal cyclooxygenase type-2 (COX-2) protein and PGE2 metabolites. Renocortical COX-2 and PGE2 levels were significantly lower in TX compared with sham and TX + R fetuses. There were no differences between sham and TX + R fetuses. These findings demonstrate that thyroid hormone positively regulates renal COX-2 and PGE2 expression in the late gestation fetal sheep kidney.

Key Words: Fetus • thyroid hormone • COX-2 • PGE2 • kidney • sheep.


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