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Reproductive Sciences
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Expression of C-kit and Platelet-Derived Growth Factor Receptors in Ovarian Granulosa Cell Tumors

Rodney P. Rocconi, MD

Department of Obstetrics and Gynecology, University of South Alabama Mitchell Cancer Institute, Mobile, Alabama, rocconi{at}usouthal.edu

Kellie S. Matthews, MD

Division of Gynecologic Oncology, University of Alabama, Birmingham, Alabama

Kristopher J. Kimball, MD

Division of Gynecologic Oncology, University of Alabama, Birmingham, Alabama

Michael G. Conner, MD

Division of Surgical pathology, University of Alabama, Birmingham, Alabama

Allyson C. Baker, MD

Division of Surgical pathology, University of Alabama, Birmingham, Alabama

Mack N. Barnes, MD

Division of Gynecologic Oncology, University of Alabama, Birmingham, Alabama

Objective. This study aimed at evaluating the expression of tyrosine kinase receptors c-kit, (platelet-derived growth factor receptor-{alpha} (PDGFR-{alpha}), and PDGFR-β in ovarian granulosa cell tumors (GCTs). Study design. Primary ovarian GCT specimens were obtained for immunohistochemical staining.The expressions of c-kit, PDGFR-{alpha}, and PDGFR-β were analyzed and scored by a semiquantitative (SQ) method. Normal ovarian tissue from the same patients' specimens served as internal controls. Results. A total of 21 specimens were available for evaluation. C-kit was expressed in only 2 samples, whereas both PDGFR-{alpha} and PDGFR-β stained positive in 100% of tumors. PDGFR targets demonstrated strong positive expression in intensity and amount of tissue stained. Normal ovarian tissue demonstrated complete absence of staining for all 3 antibodies evaluated. Conclusions. The data demonstrated significant expression of PDGFR targets of imatinib mesylate in GCTs, whereas normal ovarian tissues had a complete absence of staining.This expression profile provides the rationale to investigate the role of imatinib mesylate in PDGFR-positive GCTs.

Key Words: Granulosa cell tumors • c-kit • platelet-derived growth factor • imatinib mesylate.

This version was published on September 1, 2008

Reproductive Sciences, Vol. 15, No. 7, 673-677 (2008)
DOI: 10.1177/1933719108317584
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