SAGE Journals Online
Advertisement
Sign In to gain access to subscriptions and/or personal tools.

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Advertisement

Sign In to gain access to subscriptions and/or personal tools.
Reproductive Sciences
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
1933719108317584v1
15/7/673    most recent
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Rocconi, R. P.
Right arrow Articles by Barnes, M. N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rocconi, R. P.
Right arrow Articles by Matthews, K. S.
Right arrow Articles by Kimball, K. J.
Right arrow Articles by Conner, M. G.
Right arrow Articles by Baker, A. C.
Right arrow Articles by Barnes, M. N.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Expression of C-kit and Platelet-Derived Growth Factor Receptors in Ovarian Granulosa Cell Tumors

Rodney P. Rocconi, MD

Department of Obstetrics and Gynecology, University of South Alabama Mitchell Cancer Institute, Mobile, Alabama, rocconi{at}usouthal.edu

Kellie S. Matthews, MD

Division of Gynecologic Oncology, University of Alabama, Birmingham, Alabama

Kristopher J. Kimball, MD

Division of Gynecologic Oncology, University of Alabama, Birmingham, Alabama

Michael G. Conner, MD

Division of Surgical pathology, University of Alabama, Birmingham, Alabama

Allyson C. Baker, MD

Division of Surgical pathology, University of Alabama, Birmingham, Alabama

Mack N. Barnes, MD

Division of Gynecologic Oncology, University of Alabama, Birmingham, Alabama

Objective. This study aimed at evaluating the expression of tyrosine kinase receptors c-kit, (platelet-derived growth factor receptor-{alpha} (PDGFR-{alpha}), and PDGFR-β in ovarian granulosa cell tumors (GCTs). Study design. Primary ovarian GCT specimens were obtained for immunohistochemical staining.The expressions of c-kit, PDGFR-{alpha}, and PDGFR-β were analyzed and scored by a semiquantitative (SQ) method. Normal ovarian tissue from the same patients' specimens served as internal controls. Results. A total of 21 specimens were available for evaluation. C-kit was expressed in only 2 samples, whereas both PDGFR-{alpha} and PDGFR-β stained positive in 100% of tumors. PDGFR targets demonstrated strong positive expression in intensity and amount of tissue stained. Normal ovarian tissue demonstrated complete absence of staining for all 3 antibodies evaluated. Conclusions. The data demonstrated significant expression of PDGFR targets of imatinib mesylate in GCTs, whereas normal ovarian tissues had a complete absence of staining.This expression profile provides the rationale to investigate the role of imatinib mesylate in PDGFR-positive GCTs.

Key Words: Granulosa cell tumors • c-kit • platelet-derived growth factor • imatinib mesylate.

This version was published on September 1, 2008

Reproductive Sciences, Vol. 15, No. 7, 673-677 (2008)
DOI: 10.1177/1933719108317584
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?




Advertisement