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Reproductive Sciences
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Preeclampsia Risk and Angiotensinogen Polymorphisms M235T and AGT -217 in African American and Caucasian Women

Laura D. Jenkins, MD, MPH

Magee-Women's Research Institute, University of Pittsburgh Medical Center, Departments of Family Medicine, University of Pittsburgh School of Medicine, jenkinsld{at}upmc.edu

Robert W. Powers, PhD

Magee-Women's Research Institute, University of Pittsburgh Medical Center, Deparmtent of Obstetrics & Gynecology and Reproductive Sciences (RWP, JMR), University of Pittsburgh School of Medicine

Mary Cooper

Magee-Women's Research Institute, University of Pittsburgh Medical Center

Marcia J. Gallaher

Magee-Women's Research Institute, University of Pittsburgh Medical Center

Nina Markovic, PhD

Magee-Women's Research Institute, University of Pittsburgh Medical Center, Departments of Epidemiology, Univresity of Pittsburgh Graduate School of Public Health

Robert Ferrell, PhD

Department of Human Genetics (RF), University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania

Roberta B. Ness, MD, MPH

Magee-Women's Research Institute, University of Pittsburgh Medical Center, Departments of Epidemiology, Univresity of Pittsburgh Graduate School of Public Health

James M. Roberts, MD

Magee-Women's Research Institute, University of Pittsburgh Medical Center, Deparmtent of Obstetrics & Gynecology and Reproductive Sciences (RWP, JMR), University of Pittsburgh School of Medicine, Departments of Epidemiology, Univresity of Pittsburgh Graduate School of Public Health

Introduction: Genetic variants of the angiotensinogen gene have been linked to both hypertension and preeclampsia. The M235T polymorphism is more common in hypertension and preeclampsia in some populations. A polymorphism in the angiotensinogen basal promoter region of AGT -217 is more common in African Americans with hypertension. The authors investigated the frequency of M235T and AGT -217 in Caucasian and African American women with and without preeclampsia. Methods: The study was a nested case—control study of primiparous women with singleton pregnancies. Genomic DNA from preeclamptic and control subjects underwent polymerase chain reaction amplification and restriction digestion. Results: The M235T and AGT -217 polymorphisms were both more common in African American women; however, the variants were not more common in preeclampsia. Conclusion: The frequency of angiotensinogen polymorphisms M235T and AGT -217 is different by race; however, these polymorphisms are not associated with an incre ased risk of preeclampsia.

Key Words: Angiotensinogen polymorphisms ,preeclampsia • pregnancy • race/ethnicity.

This version was published on September 1, 2008

Reproductive Sciences, Vol. 15, No. 7, 696-701 (2008)
DOI: 10.1177/1933719108316984
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