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Reproductive Sciences
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Angiogenic Growth Factors and Their Receptors in First-Trimester Human Decidua of Pregnancies Further Complicated By Preeclampsia or Fetal Growth Restriction

M. Plaisier, MD

Department of Gynecology and Reproductive Medicine, Leiden University Medical Center, Leiden, the Netherlands, Department of Biomedical Research, TNO-QoL, Leiden, the Netherlands, m.plaisier{at}lumc.nl

E. Streefland, MD

Department of Biomedical Research, TNO-QoL, Leiden, the Netherlands

P. Koolwijk, PhD

Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, the Netherlands

V.W.M. van Hinsbergh, PhD

Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, the Netherlands

F.M. Helmerhorst, MD

Department of Gynecology and Reproductive Medicine, Leiden University Medical Center, Leiden, the Netherlands

J.J.H.M. Erwich, MD, PhD

Department of Obstetrics and Gynecology, University Medical Center Groningen, Groningen, the Netherlands

Disturbances in decidual and placental vascular development may play a role in the pathogenesis of pregnancy complications. This study focused on the role of angiogenic factors in the first trimester in the pathogenesis of preeclampsia (PE) and/or fetal growth restriction (FGR). First-trimester decidua was obtained during chorionic villous sampling.The expression of the angiogenic factors was determined by reverse transcriptase polymerase chain reaction and related to the pregnancy outcome. First-trimester decidua expressed all angiogenic factors.The differential expression of angiogenic factors appeared to be more prominent in FGR than in PE. These first-trimester samples provided a unique opportunity to obtain information regarding the onset of PE and FGR. First-trimester changes in angiogenic factor expression may well occur as a compensatory mechanism. This, in turn, may unintentionally set the stage for increased angiogenesis and altered decidual/placental vascular adaptation, which may be part of the pathogenesis of PE and/or FGR.

Key Words: Angiogenic factors • first trimester • decidua • preeclampsia • fetal growth restriction.

This version was published on September 1, 2008

Reproductive Sciences, Vol. 15, No. 7, 720-726 (2008)
DOI: 10.1177/1933719108317300
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