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Plasma and Renal Renin Concentrations in Adult Sheep After Prenatal Betamethasone Exposure

Center of Research for Obstetrics and Gynecology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, Departments of Obstetrics and Gynecology, Wake Forest University School of Medicine, Winston-Salem, North Carolina

Nancy K. Valego, PhD

Center of Research for Obstetrics and Gynecology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, Departments of Obstetrics and Gynecology, Wake Forest University School of Medicine, Winston-Salem, North Carolina

LiJun Tang, PhD

Center of Research for Obstetrics and Gynecology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, Departments of Obstetrics and Gynecology, Wake Forest University School of Medicine, Winston-Salem, North Carolina

Jorge P. Figueroa, MD, PhD

Center of Research for Obstetrics and Gynecology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, Departments of Obstetrics and Gynecology, Wake Forest University School of Medicine, Winston-Salem, North Carolina

Mark C. Chappell, PhD

Department of Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston-Salem, North Carolina

Luke C. Carey, PhD

Center of Research for Obstetrics and Gynecology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, Departments of Obstetrics and Gynecology, Wake Forest University School of Medicine, Winston-Salem, North Carolina

James C. Rose, PhD

Center of Research for Obstetrics and Gynecology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, Departments of Obstetrics and Gynecology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, jimrose{at}wfubmc.edu

This study examined whether renin expression and secretion and plasma angiotensin II (Ang II) levels were altered in adult sheep exposed to antenatal betamethasone. Pregnant sheep received injections of 0.17 mg/kg betamethasone or vehicle, at 80 and 81 days of gestation, and offspring were studied at 6 and 18 months of age. At 6 months, plasma prorenin concentrations were significantly lower in betamethasone animals (4.63 ± 0.64 vs 7.09 ± 0.83 ng angiotensin I/mL/h, P < .01). The percentage of plasma active renin was significantly higher in the betamethasone group (31.93 ± 4.09% vs 18.57 ± 2.79%, P < .01). Plasma and renocortical renin levels were similar in both groups at 18 months, but plasma renin activity was lower than at 6 months. Ang II levels were suppressed by betamethasone. The data indicate that prenatal exposure to betamethasone alters processing and secretion of renin in offspring at 6 months, but that this difference is not apparent at 18 months.

Key Words: Glucocorticoids • renin • hypertension • sodium load • renin angiotensin system • kidney.

Reproductive Sciences, Vol. 15, No. 8, 831-838 (2008)
DOI: 10.1177/1933719108318599


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