Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

SAGETRACK
Reproductive Sciences
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Agic, A.
Right arrow Articles by Hornung, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Agic, A.
Right arrow Articles by Djalali, S.
Right arrow Articles by Wolfler, M. M.
Right arrow Articles by Halis, G.
Right arrow Articles by Diedrich, K.
Right arrow Articles by Hornung, D.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Combination of CCR1 mRNA, MCP1, and CA125 Measurements in Peripheral Blood as a Diagnostic Test for Endometriosis

Admir Agic, MD

Department of Gynecology and Obstetrics, University of Schleswig-Holstein, Luebeck, Germany

Schima Djalali, MD

Department of Gynecology and Obstetrics, University of Schleswig-Holstein, Luebeck, Germany

Monika M. Wolfler, MD

Department of Gynecology and Obstetrics, Technical University of Aachen, Aachen, Germany

Gulden Halis, MD

Praxisklinik für Fertilität, Am Gendarmenmarkt, Berlin, Germany

Klaus Diedrich, MD, PhD

Department of Gynecology and Obstetrics, University of Schleswig-Holstein, Luebeck, Germany

Daniela Hornung, MD, PhD

Department of Gynecology and Obstetrics, University of Schleswig-Holstein, Luebeck, Germany, d.hornung{at}gmx.de

This study investigated the possible use of CCR1 mRNA measurement in peripheral blood leukocytes in combination with measurements of monocyte chemotactic protein-1 (MCP-1) and CA125 protein in serum as a diagnostic test for endometriosis.The expression of CCR1 mRNA in peripheral blood leukocytes was measured by quantitative real-time polymerase chain reaction. MCP-1 and CA125 levels in serum were determined by ELISA and ECLIA.The ratio of CCR1/HPRT mRNA in peripheral blood of patients with endometriosis and adenomyosis was significantly elevated compared with women without endometriosis. Additionally, serum levels of MCP-1 and CA125 were significantly higher in patients with endometriosis. This method showed a sensitivity of 92.2%, a specificity of 81.6%, a negative predictive value of 83.3%, a positive predictive value of 92.3%, a likelihood ratio of a positive test result of 5.017, and a likelihood ratio of a negative test result of 0.096 to predict the presence or absence of endometriosis.The results imply the potential use of CCR1 mRNA, MCP-1, and CA125 protein measurements for the diagnosis or exclusion of endometriosis.

Key Words: CA125 • CCR1 mRNA • diagnostic test • endometriosis • MCP-1.

Reproductive Sciences, Vol. 15, No. 9, 906-911 (2008)
DOI: 10.1177/1933719108318598
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?