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Reproductive Sciences
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Ultrastructure of Ectopic Peritoneal Lesions From Women With Endometriosis, Including Observations on the Contribution of Coelomic Mesothelium

Carolyn J. P. Jones, PhD

Maternal and Fetal Health Research Centre, School of Clinical and Laboratory Science, University of Manchester, St Mary's Hospital, Manchester, United Kingdom, carolyn.jones@ manchester.ac.uk

Luciano G. Nardo, MD

Maternal and Fetal Health Research Centre, School of Clinical and Laboratory Science, University of Manchester, St Mary's Hospital, Manchester, United Kingdom, Department of Reproductive Medicine, St Mary's Hospital, Manchester, United Kingdom

Pietro Litta, MD

Department of Obstetrics and Gynaecology, University of Padua, Padua, Italy

Asgerally T. Fazleabas, PhD

Center for Women's Health and Reproduction, Department of Obstetrics and Gynecology, University of Illinois at Chicago, Chicago, Illinois

Following a study in a baboon model of endometriosis, we here describe the morphology of ectopic peritoneal lesions in the human to examine the effects of an ectopic site on glandular structure and function. Ectopic biopsies from 17 women with endometriosis were fixed and processed for electron microscopy. Certain biopsies were also probed for intermediate filaments using immunohistochemistry. Ultrastructurally, lesions showed many different glandular morphologies with indications of delayed maturation compared to normal endometrium. Mesothelium covered some lesions and there was evidence of mesothelial invasion into the stroma. Ectopic endometriotic lesions from women with endometriosis showed ultrastructural differences from eutopic endometrium, with indications that mesothelial invasion may contribute to gland development in some lesions.

Key Words: Endometriosis • ultrastructure • human • coelomic mesothelium.

This version was published on January 1, 2009

Reproductive Sciences, Vol. 16, No. 1, 43-55 (2009)
DOI: 10.1177/1933719108324891
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