This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Pérez-López, F. R. Articles by Haya, J. Search for Related Content PubMed PubMed Citation Articles by Pérez-López, F. R. Articles by Chedraui, P. Articles by Haya, J. Social Bookmarking                         What's this?

Review Article: Vitamin D Acquisition and Breast Cancer Risk

Department of Obstetrics and Gynecology, University of Zaragoza Faculty of Medicine, Clínico de Zaragoza Hospital, Domingo Miral s/n, Zaragoza, Spain, faustino.perez{at}unizar.es

Peter Chedraui, MD, MSc

Instituto para la Salud de la Mujer, Guayaquil, Ecuador

Javier Haya, MD

Department of Obstetrics and Gynecology, Ciudad Real Hospital, Ciudad Real, Spain

Objective: The aim of the study was to focus on the association of vitamin D and breast cancer. Methods: The study of evidence concerning vitamin D's influence on the origin and development of breast cancer from a PubMed and individual searches. Results: Body sunlight exposure may reduce the prevalence of breast cancer. However, these studies correspond to global populations of different countries and regions without considering other geographic factors and individual, ethnic, and cultural factors that may affect sunlight exposure. Epidemiological analyses show that low vitamin D ingestion is associated with increased risk of breast cancer. Studies measuring serum vitamin D metabolites in women who were followed many years suggest that low circulating 25-hydroxyvitamin D₃ levels are associated with increased breast cancer risk. Conclusions: Although there are controversial results, it seems plausible that sufficient endogenous vitamin D levels may have a protective function on mammary cells, reducing breast cancer risk.

Key Words: 1,25-Dihydroxyvitamin D3 • 25-hydroxyvitamin D3 • breast cancer • vitamin D.

Reproductive Sciences, Vol. 16, No. 1, 7-19 (2009)
DOI: 10.1177/1933719108327595


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?