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Reproductive Sciences
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Clostridium botulinum Toxin A Inhibits Contractility in Pregnant Human Myometrium In Vitro

Irina D. Burd, MD, PhD

Thomas Jefferson University Hospital, Philadelphia, Pennsylvania

Amen Ness, MD

Thomas Jefferson University Hospital, Philadelphia, Pennsylvania

Paul DiMuzio, MD

Thomas Jefferson University Hospital, Philadelphia, Pennsylvania

Gong-Yi Ren, PhD

Thomas Jefferson University Hospital, Philadelphia, Pennsylvania

Thomas N. Tulenko, PhD

Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, thomas.tulenko{at}jefferson.edu

Studies were undertaken to evaluate the effect of Botulinum neurotoxin type-A (BoNTA) preparation on oxytocin-induced contractions of pregnant human myometrium in vitro. Human myometrial tissue was exposed to increasing concentrations (1-50 000 U/mL) of BoNT/A. Isometric contractions were measured using a force displacement transducer. The cumulative effect of BoNT/A on myometrial activity (time to half relaxation [TTR50], frequency, and amplitude) was evaluated. The frequency of myometrial contractions was depressed by 40% from baseline (P < .05) and relaxation time was increased by 30% (P < .05) from baseline within a narrow range of concentrations. There was no significant difference in amplitude. The observed effects were rapidly reversed after complete wash out of the tissue. BoNT/A or its analogues with more specific tissue affinity may be of value as future agents for prevention of unwanted uterine contractile activity associated with preterm labor and fetal surgery.

Key Words: Preterm labor • tocolysis • Clostridium botulinum toxin A • botox • uterine smooth muscle.

This version was published on October 1, 2009

Reproductive Sciences, Vol. 16, No. 10, 1001-1004 (2009)
DOI: 10.1177/1933719109340442
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