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Increased Circulating Levels of the Antiangiogenic Factor Endostatin in Early-Onset But Not Late-Onset Preeclampsia

Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden, anna-karin.wikstrom{at}kbh.uu.se

Anders Larsson, MD, PhD

Department of Medical Sciences, Uppsala University, Uppsala, Sweden

Helena Åkerud, MD, PhD

Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden

Matts Olovsson, MD, PhD

Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden

Changes in circulating angiogenic factors seem to play a key role in the pathogenesis of preeclampsia and it seems as if these changes are of greater importance in the pathogenesis of early-onset than of late-onset disease. Endostatin is a potent, broad spectrum antagonist of angiogenesis whose role in preeclampsia is poorly investigated. The aim of this study was to estimate whether circulating endostatin levels are altered in preeclampsia, and whether women with early-onset (before 32 weeks of gestation; n = 16) and late-onset (after 35 weeks of gestation; n = 19) preeclampsia differ in this regard. Women with early-onset, but not of late-onset preeclampsia had higher levels of endostatin than healthy pregnant women in corresponding lengths of gestation. The results of the study support the hypothesis that there is heterogeneity between early- and late-onset preeclampsia, with a stronger association between an altered angiogenic balance and early-onset than late-onset disease.

Key Words: Preeclampsia • endostatin • early-onset • late-onset.

This version was published on October 1, 2009

Reproductive Sciences, Vol. 16, No. 10, 995-1000 (2009)
DOI: 10.1177/1933719109339348


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