Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

SAGETRACK

Sign In to gain access to subscriptions and/or personal tools.
Reproductive Sciences
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
1933719109341999v1
16/11/1097    most recent
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Chen, C.
Right arrow Articles by Sun, M.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chen, C.
Right arrow Articles by Wang, W.
Right arrow Articles by Zhou, H.
Right arrow Articles by Huang, J.
Right arrow Articles by Liu, P.
Right arrow Articles by Song, T.
Right arrow Articles by Sun, M.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Pharmacokinetic Comparison Between Systemic and Local Chemotherapy by Carboplatin in Dogs

Chunlin Chen, MD

Department of Obstetrics and Gynecology, Nanfang Hospital

Wei Wang, MD

Department of Obstetrics and Gynecology, Nanfang Hospital

Hongzhen Zhou, PhD

School of Public Health and Tropical Medicine Southern Medical University, Guangzhou, Guangdong Province, P. R. China

Jingsong Huang, MD

Department of Obstetrics and Gynecology, Nanfang Hospital

Ping Liu, MD

Department of Obstetrics and Gynecology, Nanfang Hospital, lpivy{at}126.com

Tianrong Song, PhD

Department of Obstetrics and Gynecology, Nanfang Hospital

Minghui Sun, MD

Department of Obstetrics and Gynecology, Nanfang Hospital

The aim of the current study was to compare pharmacokinetics of local chemotherapy by pelvic intra-arterial administration with intravenous injection in dogs. A total of 18 female dogs (weight: 10-15 kg) were randomly divided into 3 groups: the peripheral vein administration (group A, n = 6), the abdominal aorta administration (group B, n = 6), and the internal iliac artery administration (group C, n = 6). Carboplatin at a dose of 1.2 mg/kg was administered by infusing into the arteries or the vein. For analysis, plasma and uterine tissue samples were collected at different times following infusion. The peak local concentration of platinum in the uterus of dogs in group C was significantly higher than those of groups A and B (P < .05). The area under the tissue concentration—time curve (AUC) of uterine tissues was significantly higher in dogs of group C compared to those of the other 2 groups (P < .05). There was no significant difference in the AUC of the uterine tissues of dogs between groups A and B (P > .05). The peak concentration of platinum in plasma was significantly higher in group A compared to those of the other 2 administration routes (P < .05). We observed the pharmacokinetic advantages of local chemotherapy by internal iliac artery perfusion with the chemotherapeutic agent, carboplatin, to the uterus, thereby leading to a high-drug concentration that may be more effective in treating cervical cancer.

Key Words: Intra-arterial chemotherapy • intravenous chemotherapy • carboplatin • peak value of platinum • area under the concentration—time curve (AUC).

This version was published on November 1, 2009

Reproductive Sciences, Vol. 16, No. 11, 1097-1102 (2009)
DOI: 10.1177/1933719109341999
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?