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Reproductive Sciences
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Feasibility of Ultrasound-guided Percutaneous Samplings in the Pregnant Baboon: A Model for Studies on Transplacental Transport

Kristel Van Calsteren, MD

Department of Obstetrics & Gynecology, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Belgium

Roland Devlieger, MD, PhD

Department of Obstetrics & Gynecology, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Belgium

Luc De Catte, MD, PhD

Department of Obstetrics & Gynecology, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Belgium

Thomas D'Hooghe, MD, PhD

Department of Reproductive Biology, Institute of Primate Research, Nairobi, Kenya

Daniel C. Chai, DVM

Department of Reproductive Biology, Institute of Primate Research, Nairobi, Kenya

Jason M. Mwenda, PhD

Department of Reproductive Biology, Institute of Primate Research, Nairobi, Kenya

Ignace Vergote, MD, PhD

Department of Obstetrics & Gynecology, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Belgium

Frédéric Amant, MD, PhD

Department of Obstetrics & Gynecology, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Belgium, Frederic.amant{at}uz.kuleuven.ac.be

Objective: A study was conducted to test the feasibility of cordocenteses and amniocenteses at different gestational ages in pregnant baboons. Study Design: Experiments were performed in 10 pregnant baboons at a median gestational age of 131 (range 92-169) days. At different time intervals, percutaneous samplings of amniotic fluid and fetal blood were performed under ultrasound guidance. Simultaneously, maternal blood samples were drawn. Results: With a median fetal weight of 431 g (range 111-690 g), 29 of 30 cordocenteses (96.6%) and all 30 amniocenteses and maternal samplings (100%) were successful in obtaining the required quantities for analysis. One cordocentesis was abandoned because of insufficient visualization of the umbilical cord due to a placental haemorrhage. Conclusion: Percutaneous amniocentesis and cordocentesis can be performed with a high success rate in the pregnant baboon model. In combination with a 100% success rate in obtaining simultaneous maternal blood samples, this method is able to provide data on transplacental transport.

Key Words: Amniocentesis • cordocentesis • baboon • transplacental transfer.

This version was published on March 1, 2009

Reproductive Sciences, Vol. 16, No. 3, 280-285 (2009)
DOI: 10.1177/1933719108324890
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