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Reproductive Sciences
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Na +,K+-ATPase Activity and Subunit Isoform Protein Abundance: Effects of Antenatal Glucocorticoids in the Frontal Cerebral Cortex and Renal Cortex of Ovine Fetuses

Najma S. Mehter, BS

Warren Alpert Medical School of Brown University, Department of Pediatrics, Women & Infants' Hospital of Rhode Island, Providence, Rhode Island, College of Medicine, The Ohio State University, Columbus, Ohio

Grazyna B. Sadowska, DVM

Warren Alpert Medical School of Brown University, Department of Pediatrics, Women & Infants' Hospital of Rhode Island, Providence, Rhode Island

Shadi N. Malaeb, MD

Warren Alpert Medical School of Brown University, Department of Pediatrics, Women & Infants' Hospital of Rhode Island, Providence, Rhode Island

Barbara S. Stonestreet, MD

Warren Alpert Medical School of Brown University, Department of Pediatrics, Women & Infants' Hospital of Rhode Island, Providence, Rhode Island, bstonestreet{at}wihri.org

We examined the effects of single and multiple maternal glucocorticoid courses on cerebral cortical (CC) and renal cortical (RC) Na+,K+-ATPase activity and protein isoform abundance in fetal sheep. Ewes received four dexamethasone or placebo injections in the single course (SC) groups, and the same treatment once a week for five-weeks in the multiple course (MC) groups. CC Na +,K+-ATPase a2-abundance was higher (P<0.05) and β2-abundance lower in the SC dexamethasone than placebo group, but Na+,K+-ATPase activity did not change. CC Na+,K+-ATPase activity, a1-, β1 -, and β2-abundance were lower in the MC dexamethasone than placebo group, but a2- and a3-abundance did not change. Both dexamethasone courses did not affect CC cell number. RC Na +,K+-ATPase activity, a1- and β1 -abundance were higher in the MC dexamethasone than placebo group, but did not change in the SC dexamethasone group. We conclude MC, but not a SC of dexamethasone, affect fetal cerebral and renal Na+,K+-ATPase, and MC result in differential effects on Na+,K+-ATPase in these organs.

Key Words: Brain • development • dexamethasone • kidney • steroids • sheep.

This version was published on March 1, 2009

Reproductive Sciences, Vol. 16, No. 3, 294-307 (2009)
DOI: 10.1177/1933719108325507
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