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The Prolonged Effect of Repeated Maternal Glucocorticoid Exposure on the Maternal and Fetal Leptin/Insulin-like Growth Factor Axis in Papio species

Department of Obstetrics and Gynecology, Center for Pregnancy and Newborn Research, University of Texas Health Science Center, San Antonio, Texas, Southwest National Primate Research Center, schlabritzlu{at}uthscsa.edu

Juan C. Lopez-Alvarenga, MD, PhD

Department of Genetics Southwest Foundation for Biomedical Research, San Antonio, Texas

Anthony G. Comuzzie, PhD

Southwest National Primate Research Center, Department of Genetics Southwest Foundation for Biomedical Research, San Antonio, Texas

Myrna M. Miller, DVM, PhD

United States Department of Agriculture, Arthropod-Borne Animal Diseases Research Laboratory, Agricultural Research Service, Laramie, Wyoming

Stephen P. Ford, PhD

Department of Animal Science, Center for the Study of Fetal Programming, University of Wyoming, Laramie, Wyoming

Cun Li, MD

Department of Obstetrics and Gynecology, Center for Pregnancy and Newborn Research, University of Texas Health Science Center, San Antonio, Texas

Gene B. Hubbard, DVM, MS

Southwest National Primate Research Center

Robert J. Ferry, Jr, MD

Department of Pediatrics, Section of Pediatric Endocrinology, The University of Tennessee Health Science Center, Le Bonheur Children's Medical Center and St. Jude Children's Research Hospital, Memphis, Tennessee

Peter W. Nathanielsz, MD, PhD

Department of Obstetrics and Gynecology, Center for Pregnancy and Newborn Research, University of Texas Health Science Center, San Antonio, Texas, Southwest National Primate Research Center, Department of Genetics Southwest Foundation for Biomedical Research, San Antonio, Texas

Background: Maternal obesity represents a risk factor for pregnancy-related complications. Glucocorticoids are known to promote obesity in adults. Methods: We evaluated maternal and fetal metabolic changes during and after 3 weekly courses of betamethasone administered to pregnant baboons (Papio subspecies) at doses equivalent to those given to pregnant women. Results: Betamethasone administration during the second half of pregnancy increased maternal weight but neither maternal food intake nor fetal weight, as assessed at the end of gestation. Betamethasone increased maternal serum glucose concentration, the ratio of insulin-like growth factor-I and insulin-like growth factor binding protein-3, and serum leptin during treatment (normalized by 17, 35, and 45 days posttreatment, respectively, for each parameter). Maternal and fetal serum leptin concentrations did not differ between groups at the end of gestation. Conclusion: Prolonged maternal hyperleptinemia caused by betamethasone administration in the second half of gestation did not change fetal metabolic parameters measured and placental leptin distribution at the end of gestation.

Key Words: Glucocorticoid • insulin-like growth factor • IGF-binding protein • leptin • baboon • pregnancy.

This version was published on March 1, 2009

Reproductive Sciences, Vol. 16, No. 3, 308-319 (2009)
DOI: 10.1177/1933719108325755


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