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Exercise-induced Changes in Venous Vascular Function in Nonpregnant Formerly Preeclamptic Women

Department of Obstetrics and Gynecology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands, i.krabbendam{at}obgyn.umcn.nl

Martje L. Maas, MD

Department of Obstetrics and Gynecology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

Dick H. J. Thijssen, PhD

Research Institute for Sport and Exercise Science, John Moores University, Liverpool, United Kingdom, Department of Physiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

Wim J. G. Oyen, MD, PhD

Department of Nuclear Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

Fred K. Lotgering, MD, PhD

Department of Obstetrics and Gynecology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

Maria T. E. Hopman, MD, PhD

Department of Physiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

Marc E. A. Spaanderman, MD, PhD

Objective: Formerly preeclamptic women with low plasma volume are at increased risk of recurrent gestational hypertensive disease. We hypothesized that a 4-week cycling training in formerly preeclamptic women improves (venous) hemodynamic function. Methods: In 9 formerly preeclamptic women, we examined physical fitness and hemodynamic function, before and after the training. We assessed blood pressure, heart rate, cardiac output, plasma volume, and calf and forearm venous compliance. Results: After the training, baseline blood pressure and cardiac output remained unchanged, but resting heart rate decreased (—7%, P = .02). Plasma volume was 8% higher after training (P = .01). Calf venous compliance increased (+18%, P = .02) but not forearm venous compliance (+14%, P = .09). Conclusion: Cycling training improves venous vascular function in formerly preeclamptic women. The decreased resting heart rate and improvement of venous compliance suggest reduced sympathetic activity. These rapid exercise-induced changes may improve maternal vascular adaptation in early pregnancy and with it the risk of (recurrent) gestational hypertensive disease.

Key Words: Preeclampsia • plasma volume • venous compliance • exercise • training.

This version was published on April 1, 2009

Reproductive Sciences, Vol. 16, No. 4, 414-420 (2009)
DOI: 10.1177/1933719109332091


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