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Reproductive Sciences
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Effects of Endogenous Ovarian Estrogen Versus Exogenous Estrogen Replacement on Blood Flow and ER{alpha} and ERβ Levels in the Bladder

Tova S. Ablove, MD

Division of Gynecology Subspecialties (Urogynecology), Atrium B, Meriter Hospital/Park, Madison, Wisconsin, Departments of Obstetrics and Gynecology, University of Wisconsin-Madison, Perinatal Research Laboratories

Jason L. Austin

Departments of Obstetrics and Gynecology, University of Wisconsin-Madison, Perinatal Research Laboratories

Terry M. Phernetton

Departments of Obstetrics and Gynecology, University of Wisconsin-Madison, Perinatal Research Laboratories

Ronald R. Magness, PhD

Departments of Obstetrics and Gynecology, University of Wisconsin-Madison, Perinatal Research Laboratories, Departement of Pediatrics, Atrium B, Meriter Hospital/Park, Madison, Wisconsin, Department of Animal Sciences, Atrium B, Meriter Hospital/Park, Madison, Wisconsin, rmagness{at}wisc.edu

Objective. Determine the effect of endogenous estrogen versus estrogen replacement therapy (ERT) on bladder blood flow (BBF) and estrogen receptors (ERs). Methods. BBF was determined with radiolabeled microspheres in luteal, follicular, pregnant, oophorectomized (Ovx) sheep, and Ovx sheep with ERT. Estrogen receptors (ER{alpha}, ERβ) were quantified using Western blot analysis. Results. Compared to luteal and follicular ewes, BBF was reduced in pregnancy and following oophorectomy. Estrogen replacement therapy in Ovx sheep restored BBF to luteal levels. Estrogen receptor {alpha} predominated, whereas ERβ was not detectable. Estrogen receptor-{alpha} levels were unaffected by the ovarian cycle and increased in pregnancy, as well as in Ovx sheep with and without chronic ERT. Conclusion. The combination of diminished BBF and elevated ER{alpha} levels in both pregnant and Ovx sheep suggests an inverse relationship between BBF and ER{alpha} in the bladder. Although chronic ERT in Ovx sheep restored BBF, it did not restore ER{alpha} back to luteal levels.

Key Words: Blood flow • bladder • ovarian • estrogen • progesterone.

Reproductive Sciences, Vol. 16, No. 7, 657-664 (2009)
DOI: 10.1177/1933719109334255
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