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Angiotensin-Converting Enzyme and Adducin-1 Polymorphisms in Women With Preeclampsia and Gestational Hypertension

Unit of Obstetrics and Gynecology, Department of Clinical Sciences L. Sacco, University of Milan, Italy, Centre for Fetal Research Giorgio Pardi, University of Milan, Italy, Institute of Obstetrics and Gynecology, Fondazione IRCCS Policlinico, Mangiagalli e Regina Elena, University of Milan, Italy

Patrizio Antonazzo, MD

Unit of Obstetrics and Gynecology, Department of Clinical Sciences L. Sacco, University of Milan, Italy, Centre for Fetal Research Giorgio Pardi, University of Milan, Italy

Silvia Tabano, PhD

Department of Medicine, Surgery and Dentistry, Unit of Medical Genetics, University of Milan, Italy

Susanna Zanutto, PhD

Department of Medicine, Surgery and Dentistry, Unit of Medical Genetics, University of Milan, Italy

Paola Pileri, MD

Unit of Obstetrics and Gynecology, Department of Clinical Sciences L. Sacco, University of Milan, Italy, Centre for Fetal Research Giorgio Pardi, University of Milan, Italy

Edgardo Somigliana, MD

Institute of Obstetrics and Gynecology, Fondazione IRCCS Policlinico, Mangiagalli e Regina Elena, University of Milan, Italy

Francesca Colleoni, PhD

Unit of Obstetrics and Gynecology, Department of Clinical Sciences L. Sacco, University of Milan, Italy, Centre for Fetal Research Giorgio Pardi, University of Milan, Italy, Institute of Obstetrics and Gynecology, Fondazione IRCCS Policlinico, Mangiagalli e Regina Elena, University of Milan, Italy

Anna Martinelli, MD

Unit of Obstetrics and Gynecology, Department of Clinical Sciences L. Sacco, University of Milan, Italy, Centre for Fetal Research Giorgio Pardi, University of Milan, Italy

Anna Zolin, PhD

"GA Maccacaro" Institute of Medical Statistics and Biometry, University of Milan, Italy

Chiara Benedetto, MD

Department of Obstetrics and Gynecology, University of Turin, Italy

Luca Marozio, MD

Department of Obstetrics and Gynecology, University of Turin, Italy

Isabella Neri, MD

Mother-Infant Department, University Modena and Reggio Emilia, Modena, Italy

Fabio Facchinetti, MD

Mother-Infant Department, University Modena and Reggio Emilia, Modena, Italy

Monica Miozzo, PhD

Department of Medicine, Surgery and Dentistry, Unit of Medical Genetics, University of Milan, Italy

Irene Cetin, MD

Unit of Obstetrics and Gynecology, Department of Clinical Sciences L. Sacco, University of Milan, Italy, irene.cetin{at}unimi.it, Centre for Fetal Research Giorgio Pardi, University of Milan, Italy, Institute of Obstetrics and Gynecology, Fondazione IRCCS Policlinico, Mangiagalli e Regina Elena, University of Milan, Italy

The angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism and the Adducin-1 (ADD1) G460W nonsense single nucleotide polymorphism (SNP) have previously been associated to hypertension, whereas their association with preeclampsia (PE) and gestational hypertension (GH) is still controversial. We genotyped ACE I/D, ADD1 G460W, and ADD1 S586C polymorphisms in 672 unrelated pregnant women: 204 PE (81/204 mild PE), 56 GH, and 412 controls, evaluating both their single and combined effects on these pathologies. The genotype combination of the 3 polymorphisms was not statistically different in cases versus controls, nor were ACE and ADD1 polymorphisms in GH. Nevertheless, the distribution of ACE genotypes was different in PE. This was confirmed in mild PE, whereas no significance was found in severe PE. This could suggest that different factors may lead to mild and severe PE, with ACE polymorphism playing a more important role in the mild form.

Key Words: Polymorphism • preeclampsia • gestational hypertension • angiotensin-converting enzyme • adducin-1.

This version was published on September 1, 2009

Reproductive Sciences, Vol. 16, No. 9, 819-826 (2009)
DOI: 10.1177/1933719109336612


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