Reproductive Sciences

 

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First published on March 10, 2008, doi:10.1177/1933719107312161

Reproductive Sciences 2008;15:448.

A more recent version of this article appeared on May 1, 2008

Article

The Effect of Maternal Body Condition Score Before and During Pregnancy on the Glucose Tolerance of Adult Sheep Offspring

Roselle L. Cripps, PhD*, Lucy R. Green, PhD, John Thompson, HND, Malgorzata S. Martin-Gronert, BSc, Melanie Monk, I. Sheldon, Mark A. Hanson, DPhil, C. N. Hales (deceased), PhD, and Susan E. Ozanne, PhD

* To whom correspondence should be addressed. E-mail: rlc34{at}cam.ac.uk.


  Abstract
This study investigates the effects of diet-induced changes in maternal body condition on glucose tolerance in sheep.Welsh Mountain ewes were established, by dietary manipulation, at a body condition score of 2 (lower body condition [LBCS], n = 17) or >3 (higher body condition [HBCS], n = 19) prior to and during pregnancy. Birth weight and postnatal growth were similar in LBCS and HBCS offspring. In young adulthood, LBCS offspring had increased fasting glucose levels (3.8 ±0.07 vs 3.6 ± 0.05 mM, P < .05), poorer glucose tolerance (2274 ± 22.6 vs 2161 ± 33 min/mM, P < .01), and reduced insulin secretion (0.58 ± 0.05 vs 0.71 ± 0.07 nM/min, P = .07). Increased fasting glycemia, mild glucose intolerance, and impaired initial insulin secretory response, as observed in LBCS offspring, are indictors of increased diabetes risk in humans.These findings suggest that altered maternal body composition and an imbalance between the fetal and postnatal environment influence offspring glucose tolerance.


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