Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

SAGETRACK

Sign In to gain access to subscriptions and/or personal tools.
Reproductive Sciences
This Article
Right arrow Full Text (OnlineFirst PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Singh, K.
Right arrow Articles by Pandey, S.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Singh, K.
Right arrow Articles by Agrawal, N. K.
Right arrow Articles by Khanna, A.
Right arrow Articles by Jain, M.
Right arrow Articles by Pandey, S.
Right arrowPubmed/NCBI databases
*Gene*GEO Profiles
*HomoloGene*Protein
*UniGene
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Article

Cystathionine B-Synthase 844ins68 Gene Variant and Idiopathic Male Infertility

Kiran Singh, PhD*, N. K. Agrawal, DM, A. Khanna, MD, M. Jain, MD, and S. Pandey, MS

* To whom correspondence should be addressed. E-mail: singhk4{at}rediffmail.com.


  Abstract

Male infertility is a multifactorial disorder that affects approximately 10% of couples at childbearing age, with substantial clinical and social impact. The main regulating enzymes in folate and homocysteine metabolism are methylenetetrahydrofolate reductase (MTHFR) and cystathionine {beta}-synthase (CBS). In our previous study, we showed that a mutation C677T in the gene, MTHFR is a risk factor for idiopathic male infertility in the Indian population. To assess that a common polymorphism in the cystathionine {beta}-synthase (CBS) gene (844ins68) is acting as susceptibility factor for male infertility or not, we investigated this variant in 120 idiopathic male infertile patients and 200 fertile male controls. No significant association was observed (OR = 0.8348, 95% CI: 0.1578 to 4.4164, {chi}2 = 0.040, P > .05); therefore we conclude that this common 844ins68 variant is a neutral insertion variant for idiopathic male infertility in the Indian population.

First published on August 5, 2009
Reproductive Sciences 2009, doi:10.1177/1933719109341844
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?