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Reproductive Sciences
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Article

Aberrant Processing of Plasma Vitronectin and High-Molecular-Weight Kininogen Precedes the Onset of Preeclampsia

Marion Blumenstein, PhD*, Roneel Prakash, BSc, Garth J.S. Cooper, MD, PhD, and Robyn A. North, MD, PhD

* To whom correspondence should be addressed. E-mail: m.blumenstein{at}auckland.ac.nz.


  Abstract

To date, there is no reliable test to identify women in early pregnancy at risk of developing preeclampsia. Difference gel electrophoresis (DIGE) identified the plasma proteins vitronectin (VN) and high-molecular-weight kininogen (HK) in association with preeclampsia. In a longitudinal proteomics study, the plasma of preeclamptic patients (n = 6) was compared to healthy control participants (n = 6) before the onset of preeclampsia (week 20) and at the time of presentation with clinical disease (weeks 33-36). The 75-kd single-chain VN molecule increased 1.6- to 1.9-fold in preeclampsia, whereas the 65-kd moiety of the 2-chain VN molecule decreased 1.5- to 1.7-fold compared to healthy controls (P < .05). Immunoblots revealed differences in proteolytic processing of VN and/or HK in women who develop preeclampsia or preeclampsia further complicated by small-for-gestational-age. Vitronectin and HK may prove to be useful as early markers of fibrinolytic activity and neutrophil activation, which are known to be associated with preeclampsia.

First published on August 5, 2009, doi:10.1177/1933719109342756

Reproductive Sciences 2009;16:1144.

A more recent version of this article appeared on December 1, 2009
 This version was published on August 24, 2009
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