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Reproductive Sciences
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Article

The Role of IGF-1 and Ghrelin in the Compensation of Intrauterine Growth Restriction

Marialena Kyriakakou, MD*, Ariadne Malamitsi-Puchner, MD, DSc, George Mastorakos, MD, DSc, Theodora Boutsikou, MD, DSc, Demetrios Hassiakos, MD, DSc, Ioannis Papassotiriou, PhD, and Christina Kanaka-Gantenbein, MD, DSc

* To whom correspondence should be addressed. E-mail: kyriak5{at}yahoo.gr.


  Abstract
The role of insulin-like growth factor 1 (IGF-1) and ghrelin in intrauterine growth restricted (IUGR) neonates in comparison to appropriate for gestational age (AGA) ones was investigated. Levels of IGF-1/insulin-like growth factor binding protein 3 (IGFBP3), ghrelin, insulin, and cortisol were determined in 20 singleton, full-term IUGR and 20 respective AGA neonates at birth (umbilical cord-UC), on days 1 (d1) and 4 (d4) postnatally. The ratio of IGF-1 to birth weight was higher in IUGR than in AGA in both UC (18.2 ± 1.2 vs14.4 ± 0.9, P = .05) and d1 (9.6 ± 0.5 vs 6.8 ± 0.3, P = .05). A significant positive correlation was found between IGF-1 and ghrelin levels and a negative one between IGFBP3 and ghrelin only in IUGR. In both groups, fetal IGF-1 levels negatively correlated with fetal cortisol levels. Intrauterine growth restricted neonates demonstrate a relative IGF-1 resistance in an attempt to drive energy toward survival on the expense of growth. The observed correlations between ghrelin and IGF-1/IGFBP3 postnatally indicate that ghrelin might play a role in the compensation of intrauterine undernutrition, promoting postnatal growth.

First published on September 21, 2009, doi:10.1177/1933719109344629

Reproductive Sciences 2009;16:1193.

A more recent version of this article appeared on December 1, 2009

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