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Journal of the Society for Gynecologic Investigation
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Selective Vasodilator Effects of Atrial Natriuretic Peptide in the Human Placental Vasculature

Gershon Holcberg, MD

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology; Departments of Physiology and Biophysics and Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio; University of Cincinnati College of Medicine, Department of Obstetrics and Gynecology, 231 Bethesda Avenue, Cincinnati, OH 45267-0526

Wilhelm Kossenjans, PhD

Anthony Brewer, BS

Menachem Miodovnik, MD

Leslie Myatt, PhD

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology; Departments of Physiology and Biophysics and Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio

Objective: To determine whether atrial natriuretic peptide (ANP) attenuates the vasocon-strictor effects of angiotensin II (AII), a thromboxane mimetic (U46619), and endothelin-1 in the human fetal-placental vasculature and to determine whether nitric oxide (NO) has a role in the vasodilator activity of ANP.

Methods: Isolated placental cotyledons were dually perfused, with fetal perfusion pressure used as an index of vascular response. The effects of AII (10-10-10-6 mol/L bolus injection), endothelin-1 (10-7 mol/L bolus), and U46619 (10-9-10-6 mol/L bolus or 10-8 mol/L infusion) were established in the absence or presence of ANP (10-8 mol/L). The role of NO as a mediator of ANP action was investigated by perfusion with n-nitro-L-arginine (NNLA, 10-3 mol/L), an inhibitor of NO synthase. Statistical significance was determined by analysis of variance.

Results: Atrial nutriuretic peptide caused significant attenuation of vasoconstrictor responses to AII, but weak attenuation of endothelin-1 and no attenuation of U46619. Use of NNLA did not affect the attenuation of AII-induced vasoconstriction by ANP.

Conclusion: Atrial natriuretic peptide is a vasodilator of the fetal-placental vasculature constricted with AII and endothelin-1, but not with U46619. Nitric oxide does not mediate the action of ANP.

Key Words: Atrial natriuretic peptide • placenta • nitric oxide • angiotensin • thromboxane mimetic • endothelin-1

Journal of the Society for Gynecologic Investigation, Vol. 2, No. 1, 1-5 (1995)
DOI: 10.1177/107155769500200101
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