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Journal of the Society for Gynecologic Investigation
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The Effect of Acute Ethanol Ingestion on Estrogen Levels in Postmenopausal Women Using Transdermal Estradiol

Elizabeth S. Ginsburg, MD

Brian W. Walsh, MD

Xiaoping Gao, MD

Ray E. Gleason, PhD

Colleen Feltmate

Robert L. Barbieri, MD

Departments of Obstetrics, Gynecology, and Reproductive Biology, and Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts

Objective: To determine whether acute alcohol ingestion raises estradiol (E2) and estrone (E1) levels in a randomized, controlled, crossover study on postmenopausal women using transdermal E2.

Methods: Healthy, non-smoking postmenopausal women (n = 7) using no medications were enrolled. Transdermal E2, 0.15 mg, was applied 13 hours before the subjects ingested alcohol (1 mL/kg 95% ethanol) or isocaloric carbohydrate punch. Serum samples were obtained for 40 minutes before drink ingestion and 6 hours after drink ingestion and were assayed for E2 and E1.

Results: Ethanol levels peaked 60 minutes after the start of ethanol-drink ingestion, at 25.4 mmol/L (117 mg/dL). Estradiol levels rose significantly above the mean baseline of 657 pmol/L (179 pg/mL) after ethanol-drink ingestion (P ≤ .01), with a mean peak of 804 pmol/L (219 pg/mL) 35 minutes after the start of drink ingestion, and were significantly greater than the E2 levels that followed the carbohydrate drink (P ≤ .0001). There were no significant changes in E2 or E1 levels after carbohydrate-drink ingestion.

Conclusions: We conclude that ethanol ingestion may acutely raise circulating E2 concentrations in women using transdermal E2.

Key Words: Ethanol • estradiol • estrone • menopause

Journal of the Society for Gynecologic Investigation, Vol. 2, No. 1, 26-29 (1995)
DOI: 10.1177/107155769500200106
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