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Human Placental Transfer of the Prostaglandin Inhibitor Sulindac Using an In Vitro Model

Departments of Obstetrics and Gynecology and Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas; Department of Obstetrics and Gynecology, Brooke Army Medical Center, Fort Sam Houston, TX 78234-6200

Byron Elliott, MD

Thomas S. King, PhD

Diana Frasier

Oded Langer, MD

Departments of Obstetrics and Gynecology and Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas

Objective: We determined whether the prostaglandin inhibitor sulindac crosses the human placenta.

Methods: The recirculating single-cotyledon placenta model was used to characterize the matenal-to-fetal and fetal-to-maternal transport of ¹⁴C-labeled sulindac in normal term placentas perfused immediately after delivery. Antipyrine was added as a standard for simple diffusion. Serial samples were taken from bth reservoirs during each 3-hour perfusion. Transport was calculated using liquid scitntillation spectrometry for ¹⁴C-labeled sulindac and high-performance liquid chromatography for antipyrine.

Results: There was significant maternal-to-fetal transfer of sulindac. The mean (±SD) transfer at 2 hours was 7.22 ± 2.57%. The fetal-to-maternal transfer was similar at 10.75 ± 3.80%. The mean maternal/fetal concentration ratio of sulindac was 0.42 at 3 hours. Placental uptake ranged from 24-45 ng/g of placenta.

Conclusions: Sulindac crosses the human placenta in small but significant amounts. The transport is similar in both directions, implying simple diffusion.

Key Words: Sulindac • prostaglandin inhibitors • placental transfer

Journal of the Society for Gynecologic Investigation, Vol. 2, No. 3, 526-530 (1995)
DOI: 10.1177/107155769500200304


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