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Journal of the Society for Gynecologic Investigation
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Reviews

Insulin-Like Growth Factors as Determinants of Follicular Fate

Eli Y. Adashi, MD

Division of Reproductive Endocrinology, Departments of Obstetrics/Gynecology and Physiology, University of Maryland School of Medicine, Baltimore, Maryland

Objective: To review the English-language literature as it relates to the rat intraovarian insulin-like growth factor (IGF) systgem, special emphasis being placed on the hypotheses under study.

Methods: A thorough literature review of the English-language literature.

Results: Current data support the view that intraovarian IGF-I may act as an amplifier of gonadotropin hormonal action. The role of IGF-I as a determinant of follicular fate remains a matter of study.

Conclusions: The intraovarian IGF-I system may play a central role in ovarian physiology by amplifying gonadotropin hormonal action and, possibly, by playing a role in determining follicular fate.

Key Words: Ovary • folliculogenesis • insulin-like growth factor-I

Journal of the Society for Gynecologic Investigation, Vol. 2, No. 6, 721-726 (1995)
DOI: 10.1177/107155769500200601
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