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Similarity of Insulin-Dependent Diabetics' and Non-Insulin-Dependent Diabetics' Levels of ß-hCG and Unconjugated Estriol With Controls: No Need to Adjust as With Alpha-Fetoprotein

Joseph E. O'Brien, MD

Elena Dvorin, PhD

Eric L. Krivchenia, MS

Arie Drugan, MD

Roderick F. Hume, Jr., MD

Mark P. Johnson, MD

Departments of Obstetrics and Gynecology, Molecular Medicine and Genetics, and Pathology, Hutzel Hospital/Wayne State University, Detroit, Michigan, the Department of Pathology, Columbia University, New York, New York, Corning/MetPath Inc., Teterboro, New Jersey, and Auburn Hills, Michigan; Department of Obstetrics, Rambam Medical Center, Haifa, Israel

Objective: To determine if the same systematic alteration of serum values seen for alpha-fetoprotein (AFP) in diabetic patients is also seen for ß-hCG and unconjugated estriol (uE3).

Methods: Serum AFP, ß-hCG, and uE3 results were obtained in 18,639 patients for whom complete follow-up information was obtained. Patients were divided into euglycemic (n = 18,088), insulin-requiring diabetics (n = 104), and non-insulin-requiring diabetics (n = 437), as well as by race.

Results: The 20% adjustment used for AFP appropriately corrects serum values. No such systematic variation is seen for either ß-hCG or uE3 by glycemic status or race.

Conclusion: No adjustment for ß-hCG or uE3 is necessary for diabetes for biochemical screening programs.

Key Words: Insulin • diabetes • screening programs • multiple marker biochemical screening

Journal of the Society for Gynecologic Investigation, Vol. 3, No. 1, 20-22 (1996)
DOI: 10.1177/107155769600300105


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